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AAV Vector Engineering

We are developing custom recombinant adeno-associated viruses (AAVs) for more efficient and targeted gene transfer in vivo.

Tropism is a synergy of capsid, genome, and route of administration

Multiplexed Cre-recombination-based AAV-targeted evolution

Plasmids now available on Addgene rAAV9-CAP-in-cis-Lox-AAV & AAV2/9 REP-AAP-ΔCAP

Space constraints necessitate clever design

miRNA target sites refine transgene expression profiles

Vector-assisted spectral tracing (VAST): bright labeling & tunable sparcity

Engineered opsins to pair with systemic AAV administration

Systemic AAVs in action

AAV Publications