Repository of published systemic AAV experiments
Updated August 13th 2024
Capsid | Result | Species | Target | Promoter | Cargo | Dose | Injection | Incubation | Doi | Addgene Genome |
---|---|---|---|---|---|---|---|---|---|---|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
104061 |
|
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
104061 |
|
PHP.S |
NEG |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
1E12 vg/animal |
RO |
3 weeks |
104061 |
|
PHP.S |
POS |
Mouse, C57BL/6J |
PNS, all |
CAG |
FP |
1E12 vg/animal |
RO |
3 weeks |
104061 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, astrocytes |
GFAP |
FP |
1E12 vg/animal |
RO |
3 weeks |
99129 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, oligodendrocytes |
MBP |
FP |
1E12 vg/animal |
RO |
3 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, neurons |
hSyn1 |
FP |
1E12 vg/animal |
RO |
3 weeks |
99135 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, serotonergic neurons |
Ple67 |
FP |
1E12 vg/animal |
RO |
3 weeks |
49138 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, catecholaminergic neurons |
mTH |
FP |
1E12 vg/animal |
RO |
2 weeks |
99128 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, purkinje neurons |
Ple155 |
FP |
1E12 vg/animal |
RO |
4 weeks |
49140 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, gabaergic interneurons |
mDLX |
FP |
3E11 vg/animal |
RO |
8 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
1E12 vg/animal |
RO |
3 weeks |
37825 |
|
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
37825 |
|
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
2E12 vg/animal |
RO |
3 weeks |
37825 |
|
PHP.B |
POS |
Mouse, GAD2-Cre |
CNS, excitatory neurons |
CaMKIIa |
Sensor jRCaMP1b |
1E12 vg/animal |
RO |
4 weeks |
||
PHP.B |
POS |
Mouse, GAD2-Cre |
CNS, GAD+ neurons |
EF1a DIO |
Sensor GCaMP6f |
1E12 vg/animal |
RO |
4 weeks |
||
PHP.B |
POS |
Mouse, SST-Cre |
CNS, SST+ neurons |
CAG DIO |
Sensor GCaMP6f |
1E12 vg/animal |
RO |
4 weeks |
||
PHP.B |
POS |
Mouse, PV-Cre |
CNS, PV+ neurons |
CAG DIO |
Sensor GCaMP6f |
1E12 vg/animal |
RO |
4 weeks |
||
PHP.B |
POS |
Mouse, Tac2-Cre |
CNS, Tac2+ neurons |
hSyn1 DIO |
Rescue P2A FP |
5E11 vg/animal |
RO |
3 weeks |
||
PHP.B |
POS |
Mouse, Tac2-Cre |
CNS, Tac2+ neurons |
hSyn1 DIO |
Rescue P2A FP |
5E11 vg/animal |
RO |
3 weeks |
||
PHP.B |
POS |
Mouse, Tac2-Cre |
CNS, Tac2+ neurons |
hSyn1 DIO |
Chemogenetic hM3D(Gq) |
5E11 vg/animal |
RO |
3 weeks |
44361 |
|
PHP.B |
POS |
Mouse, Tac2-Cre |
CNS, Tac2+ neurons |
hSyn1 DIO |
FP |
5E11 vg/animal |
RO |
3 weeks |
50459 |
|
PHP.B |
POS |
Mouse, Trim9 -/- |
CNS, all |
CAG |
Rescue |
1.5E12 vg/animal |
RO |
3 weeks |
||
PHP.B |
POS |
Mouse, Trim9 -/- |
CNS, all |
CAG |
FP |
1.5E12 vg/animal |
RO |
3 weeks |
||
PHP.S |
POS |
Mouse, Chat-Cre |
PNS, cardiac ganglia, cholinergic neurons |
CAG DIO |
FP |
3E12 vg/animal |
RO |
3 weeks |
104058, 104059 |
|
PHP.S |
POS |
Mouse, Chat-Cre |
PNS, cardiac ganglia, cholinergic neurons |
CAG DIO |
FP |
1E12 vg/animal |
RO |
3 weeks |
127090 |
|
PHP.S |
POS |
Mouse, Chat-Cre |
PNS, cardiac ganglia, cholinergic neurons |
CAG DIO |
Opsin, ChR2(H134R)-FP |
1E12 vg/animal |
RO |
5 weeks |
||
PHP.eB |
POS |
Mouse, Nf1+/- |
CNS, catecholaminergic neurons |
rTh |
FP |
1E11 vg/animal |
RO |
<3 weeks |
133268, 99131, 99114, 99113 |
|
PHP.eB |
NEG |
Mouse, C57BL/6J |
CNS, cortical neurons |
hSyn1 |
Opsin, ChR2(H134R)-FP |
5E11 vg/animal |
RO |
|||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, cortical neurons |
hSyn1 |
Opsin, ChRger2 |
5E11 vg/animal |
RO |
127237 |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, cortical neurons |
hSyn1 |
Opsin, CoChR |
1E11 vg/animal |
RO |
|||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, cortical neurons |
hSyn1 |
Opsin, ChRger2 |
1E11 vg/animal |
RO |
127237 |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, excitatory neurons |
CaMKIIa |
Opsin, CoChR |
1E11 vg/animal |
RO |
|||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, excitatory neurons |
CaMKIIa |
Opsin, ChRger2 |
1E11 vg/animal |
RO |
127238 |
||
PHP.eB |
NEG |
Mouse, Dat-Cre |
CNS, dopaminergic neurons |
CAG DIO |
Opsin, ChR2(H134R)-FP |
3E11 vg/animal |
RO |
3 weeks |
||
PHP.eB |
POS |
Mouse, Dat-Cre |
CNS, dopaminergic neurons |
CAG DIO |
Opsin, ChRger2 |
3E11 vg/animal |
RO |
3 weeks |
127239 |
|
PHP.eB |
NEG |
Mouse, C57BL/6J |
CNS, excitatory neurons |
CaMKIIa |
Opsin, ChR2(H134R)-FP |
5E11 vg/animal |
RO |
3 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, excitatory neurons |
CaMKIIa |
Opsin, ChRger2 |
5E11 vg/animal |
RO |
3 weeks |
127238 |
|
PHP.S |
POS |
Mouse, C57BL/6J aged |
PNS, myenteric neurons |
hSyn1-tTA TRE |
Rescue |
3.5E11 vg/animal |
RO |
2 weeks, 10 weeks |
99120 |
|
PHP.S |
POS |
Mouse, C57BL/6J aged |
PNS, myenteric neurons |
hSyn1-tTA TRE |
Sensor, jRGECO1a |
3.5E11 vg/animal |
RO |
2 weeks, 10 weeks |
99120 |
|
PHP.S |
POS |
Mouse, C57BL/6J aged |
PNS, myenteric neurons |
hSyn1-tTA TRE |
Opsin, ChR2(H134R)-FP |
1E11 vg/animal |
RO |
2 weeks, 10 weeks |
||
PHP.S |
POS |
Mouse, ASO aged |
PNS, myenteric neurons |
hSyn1-tTA TRE |
Rescue |
3.5E11 vg/animal |
RO |
2 weeks, 10 weeks |
||
PHP.S |
POS |
Mouse, ASO aged |
PNS, myenteric neurons |
hSyn1-tTA TRE |
Sensor, jRGECO1a |
3.5E11 vg/animal |
RO |
2 weeks, 10 weeks |
||
PHP.S |
POS |
Mouse, ASO aged |
PNS, myenteric neurons |
hSyn1-tTA TRE |
Opsin, ChR2(H134R)-FP |
1E11 vg/animal |
RO |
2 weeks, 10 weeks |
||
PHP.eB |
POS |
Mouse, FVB/B6 |
CNS, neurons |
hSyn1 |
shRNA FP |
RO |
5 weeks |
|||
PHP.V1 |
POS |
Mouse, C57BL/6J |
CNS, endothelial astrocytes |
CAG |
FP |
3E11 vg/animal |
RO |
3 weeks |
99134 |
|
PHP.V1 |
POS |
Mouse, Tek-Cre |
CNS, endothelial |
CAG DIO |
FP |
1E12 vg/animal |
RO |
4 weeks |
104052 |
|
PHP.V1 |
POS |
Mouse, Ai14 |
CNS, endothelial |
Ple261 |
iCre |
3E11 vg/animal |
RO |
4 weeks |
49113 |
|
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
104061, 99134 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
104061, 99134 |
|
PHP.C1 |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
104061, 99134 |
|
PHP.N |
POS |
Mouse, C57BL/6J |
CNS, neurons |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
104061, 99134 |
|
PHP.N |
POS |
Mouse, C57BL/6J |
CNS, neurons |
CAG |
FP |
2E11 vg/animal |
RO |
3 weeks |
104061, 99134 |
|
PHP.V1 |
NEG |
Mouse, BALB/cJ |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
104061, 99134 |
|
PHP.N |
NEG |
Mouse, BALB/cJ |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
104061, 99134 |
|
PHP.B |
NEG |
Mouse, BALB/cJ |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
104061, 99134 |
|
PHP.V1 |
POS |
Mouse, FVB |
CNS, endothelial astrocytes |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
104061, 99134 |
|
PHP.N |
POS |
Mouse, FVB |
CNS, neuron |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
104061, 99134 |
|
PHP.C2 |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
104061, 99134 |
|
PHP.C3 |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
104061, 99134 |
|
PHP.C1 |
POS |
Mouse, BALB/cJ |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
104061, 99134 |
|
PHP.C2 |
POS |
Mouse, BALB/cJ |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
104061, 99134 |
|
PHP.C3 |
POS |
Mouse, BALB/cJ |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
104061, 99134 |
|
PHP.V2 |
POS |
Mouse, C57BL/6J |
CNS, endothelial astrocytes |
CAG |
FP |
3E11 vg/animal |
RO |
3 weeks |
104061, 99134 |
|
PHP.V2 |
POS |
Mouse, Tek-Cre |
CNS, endothelial |
CAG DIO |
FP |
1E12 vg/animal |
RO |
4 weeks |
104052 |
|
PHP.V2 |
POS |
Mouse, GFAP-Cre |
CNS, astrocytes |
CAG DIO |
FP |
1E12 vg/animal |
RO |
4 weeks |
104052 |
|
PHP.V1 |
POS |
Mouse, C57BL/6J |
CNS, astrocytes |
GfABC1D |
FP |
1E12 vg/animal |
RO |
4 weeks |
104053 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, astrocytes |
GfABC1D |
FP |
1E12 vg/animal |
RO |
4 weeks |
104053 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
1.5E10 vg/animal |
Tail vein |
3 weeks |
37825 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, neurons |
hSyn1 |
FP |
1E11 vg/animal |
RO |
3-4 weeks |
163509 |
|
CAP-B10 |
POS |
Mouse, C57BL/6J |
CNS, neurons |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
104061 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, neurons, astrocyte bias, oligodendrocytes |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
104061 |
|
PHP.eB |
NHP, marmoset |
CNS, all |
CAG |
HA-FXN |
7E13 vg/kg |
femoral vein, cephalic vein, saphenous vein |
32 - 42 days |
|||
CAP-B10 |
POS |
NHP, marmoset |
CNS, neuron bias, cortical, sub-cortex, cerebellum, spinal cord, dorsal root ganglia (DRG) |
CAG |
HA-FXN |
7E13 vg/kg |
femoral vein, cephalic vein, saphenous vein |
32 - 42 days |
||
CAP-B22 |
POS |
NHP, marmoset |
CNS, cortex, astrocyte bias |
CAG |
HA-FXN |
7E13 vg/kg |
femoral vein, cephalic vein, saphenous vein |
32 - 42 days |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, retinal neurons, photoreceptors |
CAG |
FP |
1E11 vg/animal |
RO |
5 weeks |
59462 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, retinal neurons, photoreceptors |
CAG |
FP |
1E10 vg/animal |
Subretinal |
5 weeks |
59462 |
|
PHP.eB |
NEG |
Mouse, C57BL/6J |
CNS, retinal neurons, photoreceptors |
CAG |
FP |
1E10 vg/animal |
Intravitreal |
5 weeks |
59462 |
|
PHP.eB |
POS |
Rat, Sprague-Dawley |
CNS, all |
CAG |
FP |
1.2E13 vg/kg |
Tail vein |
4 weeks |
||
PHP.eB |
POS |
Rat, Sprague-Dawley |
CNS, all |
CAG |
FP |
3.6E13 vg/kg |
Tail vein |
4 weeks |
||
PHP.eB |
POS |
Rat, Sprague-Dawley |
CNS, all |
CAG |
FP |
1.2E14 vg/kg |
Tail vein |
4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, excitatory neurons |
CaMKIIa |
FP |
IV |
3 weeks |
|||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, inhibitory interneurons |
mDLX |
FP |
IV |
3 weeks |
|||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, astrocytes, glutamatergic neurons, GABAergic neurons |
CAG-NLS |
FP |
1.5E11vg/animal |
RO |
3-4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, astrocytes, neurons |
CAG-NLS |
FP |
1.5E11vg/animal |
RO |
3-4 weeks |
||
CAP-B10 |
POS |
Mouse, C57BL/6J |
CNS, glutamatergic neurons bias, GABAergic neurons, astrocytes |
CAG-NLS |
FP |
1.5E11vg/animal |
RO |
3-4 weeks |
||
CAP-B10 |
POS |
Mouse, C57BL/6J |
CNS, neurons bias, astrocytes |
CAG-NLS |
FP |
1.5E11vg/animal |
RO |
3-4 weeks |
||
PHP.V1 |
POS |
Mouse, C57BL/6J |
CNS, endothelial vascular cells bias, Myoc+ astrocytes |
CAG-NLS |
FP |
1.5E11vg/animal |
RO |
3-4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, astrocytes (neuronal tropism not analyzed in this assay) |
CAG-NLS |
FP |
1.5E11vg/animal |
RO |
3-4 weeks |
||
PHP.V1 |
POS |
Mouse, C57BL/6J |
CNS, endothelial vascular cells bias, Myoc+ astrocytes |
CAG-NLS |
FP, RNA barcode |
1.5E11vg/animal |
RO |
3-4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, astrocytes (neuronal tropism not analyzed in this assay) |
CAG-NLS |
FP, RNA barcode |
1.5E11vg/animal |
RO |
3-4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, endothelial vascular cells bias, Myoc- astrocytes |
CAG-NLS |
FP |
1.5E11vg/animal |
RO |
3 days |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, Myoc- astrocytes bias, glutamatergic neurns, GABAergic neurons, endothelial vascular cells |
CAG-NLS |
FP |
1.5E11vg/animal |
RO |
25 days |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, Myoc- astrocytes |
UBC |
FP, RNA barcode |
1.5E11 vg/variant (1.05E12/animal) |
RO |
3 weeks |
||
CAP-B10 |
POS |
Mouse, C57BL/6J |
CNS, glutamatergic neurons |
UBC |
FP, RNA barcode |
1.5E11 vg/variant (1.05E12/animal) |
RO |
3 weeks |
||
PHP.V1 |
POS |
Mouse, C57BL/6J |
CNS, endothelial vascular cells |
UBC |
FP, RNA barcode |
1.5E11 vg/variant (1.05E12/animal) |
RO |
3 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, GABAergic neurons |
UBC |
FP, RNA barcode |
1.5E11 vg/variant (1.05E12/animal) |
RO |
3 weeks |
||
PHP.C1 |
NEG |
Mouse, C57BL/6J |
CNS, all |
UBC |
FP, RNA barcode |
1.5E11 vg/variant (1.05E12/animal) |
RO |
3 weeks |
||
PHP.C2 |
POS |
Mouse, C57BL/6J |
CNS, Myoc- astrocytes, endothelial vascular cells, and vascular LMCs |
UBC |
FP, RNA barcode |
1.5E11 vg/variant (1.05E12/animal) |
RO |
3 weeks |
||
PHP.B |
POS |
Mouse, Npc1m1N/m1N |
CNS, hippocampus, striatum, cerebelllar molecular cell layer, and vestibular nucleus |
EF1a(s) |
FP |
1.21E12 vg/animal |
RO |
5.5 weeks |
10.26508/lsa.202101040 |
|
PHP.B |
POS |
Mouse, Npc1+/+ |
CNS, hippocampus, striatum, cerebelllar molecular cell layer, and vestibular nucleus |
EF1a(s) |
FP |
1.21E12 vg/animal |
RO |
5.5 weeks |
10.26508/lsa.202101040 |
|
PHP.B |
POS |
Mouse, Npc1m1N/m1N |
CNS, cerebrum and cerebellum |
EF1a(s) |
Rescue |
1.43E12 vg/animal |
RO |
5.5 weeks |
10.26508/lsa.202101040 |
|
PHP.eB |
POS |
Mouse, 5xFAD |
CNS, all |
hSyn1 |
CRISPR, SaCas9, sgRNA |
1E13 vg/animal |
RO |
3 months |
10.1038/s41551-021-00759-0 |
|
PHP.eB |
POS |
Mouse, 5xFAD |
CNS, hippocampus, cortex, medulla, and brain stem |
hSyn1 |
CRISPR, SaCas9, sgRNA |
1E13 vg/animal |
RO |
3 months |
10.1038/s41551-021-00759-0 |
|
PHP.eB |
POS |
Mouse, Aldh1l1-Cre/ERT2 |
CNS, astrocytes, kidney, liver |
CAG-FLEx |
FP, Rescue, iBARK-mCherry |
1E12 vg/animal |
RO |
4 weeks |
117693 |
|
PHP.eB |
POS |
Mouse, Aldh1l1-Cre/ERT2 |
CNS, astrocytes, kidney, liver |
CAG-FLEx |
FP, Rescue, iBARK D110A-mCherry |
1E12 vg/animal |
RO |
4 weeks |
117694 |
|
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, cortial, striatal, and hippocampal neurons |
CAG |
FP |
1E11 vg/animal |
Tail vein |
3 weeks |
||
PHP.B |
NEG |
Mouse, CBA/Ca |
CNS, all |
CAG |
FP |
1E11 vg/animal |
Tail vein |
3 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
Liver and CNS, cortex, striatum, hippocampus, cerebellum, brainstem |
CAG |
FP |
1E11 vg/animal |
Tail vein |
2 hours |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, cortex, pyramidal tract (PT) neurons in L5 layer |
mscRE4-pBCmin |
FP |
1E11 vg/animal |
RO |
2 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, cortex, pyramidal tract (PT) neurons in L5 layer bias |
mscRE4-pBCmin |
FP |
1-4E10 vg/site |
Intracranial (VISp) |
|||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, cortex, intratelencephalic (IT) neurons in L5 layer bias |
mscRE16-pBCmin |
FP |
1-4E9 vg/site |
Intracranial (VISp) |
|||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, cortex, pyramidal tract (PT) neurons in L5 layer |
3x Core mscRE4-pCMVmin |
FP |
1E11 vg/animal |
RO |
3 weeks |
||
PHP.eB |
POS |
Mouse, Ai65F |
CNS, cortex, pyramidal tract (PT) neurons in L5, dense labeling |
mscRE4-pBCmin |
Recombinase, FlpO |
1E11 vg/animal |
RO |
2-3 weeks |
||
PHP.eB |
POS |
Mouse, Ai14 |
CNS, cortex nonspecific |
mscRE4-pBCmin |
Recombinase, dgCre |
1E11 vg/animal |
RO |
2-3 weeks |
||
PHP.eB |
POS |
Mouse, Ai14 |
CNS, cortex exitatory neurons in L5 and L6 |
mscRE4-pBCmin |
Recombinase, iCre |
1E11 vg/animal |
RO |
2-3 weeks |
||
PHP.eB |
POS |
Mouse, Ai63 |
CNS, cortex, neurons in L5, sparse labeling |
mscRE4-pBCmin |
Inducer, tTA2 |
1E11 vg/animal |
RO |
2-3 weeks |
||
PHP.eB |
POS |
Mouse, Ai65F |
CNS, cortex, pyramidal tract (PT) neurons in L5, dense labeling |
mscRE4-pBCmin |
Recombinase, FlpO |
1E11 vg/animal |
RO |
2-3 weeks |
||
PHP.eB |
POS |
Mouse, Ai65F |
CNS, cortex, corticothamic (CT) neurons in L6 bias, sparse labeling |
mscRE10-pBCmin |
Recombinase, FlpO |
1E10 vg/animal |
RO |
2-3 weeks |
||
PHP.eB |
POS |
Mouse, Ai65F |
CNS, cortex, CT, IT, and PT neurons in L5 and L6 |
mscRE13-pBCmin |
Recombinase, FlpO |
1E11 vg/animal |
RO |
2-3 weeks |
||
PHP.eB |
POS |
Mouse, Ai65F |
CNS, cortex, intratelencephalic (IT) neurons in L5 bias |
mscRE16-pBCmin |
Recombinase, FlpO |
1E11 vg/animal |
RO |
2-3 weeks |
||
PHP.eB |
POS |
Mouse, Ai65F/wt; Ai140/wt (double reporter) |
CNS, cortex, intratelencephalic (IT) neurons in L5 |
mscRE16-pBCmin |
Recombinase, FlpO |
1E11 vg/animal |
RO |
2 weeks |
||
PHP.eB |
POS |
Mouse, Ai65F/wt; Ai140/wt (double reporter) |
CNS, cortex, pyramidal tract (PT) neurons in L5 |
mscRE4-pBCmin |
Recombinase, iCre |
1E11 vg/animal |
RO |
2 weeks |
||
PHP.eB |
POS |
Mouse, Ai213 (triple-recombinase reporter) |
CNS, cortex, neurons |
pSyn |
Recombinase, Cre |
1E11 vg/animal |
RO |
2 weeks |
||
PHP.eB |
POS |
Mouse, Ai213 (triple-recombinase reporter) |
CNS, cortex, neurons |
pSyn |
Recombinase, FlpO |
1E11 vg/animal |
RO |
2 weeks |
||
PHP.eB |
POS |
Mouse, Ai213 (triple-recombinase reporter) |
CNS, cortex, neurons |
pSyn |
Recombinase, oNigri |
1E11 vg/animal |
RO |
2 weeks |
||
PHP.eB |
POS |
Mouse, Ai213 (triple-recombinase reporter) |
CNS, cortex, pan-neuronal |
pSyn |
Recombinase, Cre |
1E11 vg/animal |
RO |
2 weeks |
||
PHP.eB |
POS |
Mouse, Ai213 (triple-recombinase reporter) |
CNS, cortex, pan-neuronal |
pSyn |
Recombinase, FlpO |
1E11 vg/animal |
RO |
2 weeks |
||
PHP.eB |
POS |
Mouse, Ai213 (triple-recombinase reporter) |
CNS, cortex, pan-neuronal |
pSyn |
Recombinase, oNigri |
1E11 vg/animal |
RO |
2 weeks |
||
PHP.eB |
POS |
Mouse, Ai213 (triple-recombinase reporter) |
CNS, cortex, distinct neuronal subclasses |
hl56i |
Recombinase, iCre-4X2C |
1E11 vg/animal |
RO |
2 weeks |
||
PHP.eB |
POS |
Mouse, Ai213 (triple-recombinase reporter) |
CNS, cortex, distinct neuronal subclasses |
mscRE4 |
Recombinase, FlpO |
1E11 vg/animal |
RO |
2 weeks |
||
PHP.eB |
POS |
Mouse, Ai213 (triple-recombinase reporter) |
CNS, cortex, distinct neuronal subclasses |
mscRE16 |
Recombinase, oNigri |
1E11 vg/animal |
RO |
2 weeks |
||
PHP.eB |
POS |
Human, neocortical slice culture |
CNS, cortex, sparse labeling L2-L6 |
mscRE4 |
FP, Recombinase, FlpO |
direct application to slice |
||||
PHP.S |
POS |
Mouse, NAMPT:MPZ-Cre |
PNS, DRG neurons |
hSyn1 |
FP |
Intrathecal |
2 weeks |
50465 |
||
PHP.S |
POS |
Mouse, C57BL/6J |
CNS, cerebellum vestibular ganglion neurons |
CAG |
FP |
3.4E11 vg/animal |
posterior semicircular canal |
2 weeks |
59462 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, neurons |
hSyn1-H2B |
FP |
2-3E11 vg/animal |
RO |
3-4 weeks |
10.1016/j.celrep.2021.108754 |
163509 |
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, telencephalic interneurons |
hDLXI56i-minBG |
FP |
2-3E11 vg/animal |
RO |
3-4 weeks |
10.1016/j.celrep.2021.108754 |
163493 |
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, SLC17a7+ neurons, excitatory IT neurons in L56 bias |
eHGT_078h-minBG |
FP |
2-3E11 vg/animal |
RO |
3-4 weeks |
10.1016/j.celrep.2021.108754 |
163495 |
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, RORB+ neurons in L4, excitatory IT neurons in L56 |
eHGT_058h-minBG |
FP |
2-3E11 vg/animal |
RO |
3-4 weeks |
10.1016/j.celrep.2021.108754 |
163494 |
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, LAMP5+ inhibitory neurons |
eHGT_019h-minBG |
FP |
2-3E11 vg/animal |
RO |
3-4 weeks |
10.1016/j.celrep.2021.108754 |
163496 |
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, SST+ neuronal bias, VIP+ neurons |
eHGT_017h-minBG |
FP |
2-3E11 vg/animal |
RO |
3-4 weeks |
10.1016/j.celrep.2021.108754 |
163497 |
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, PVALB+ neurons |
eHGT_128h-minRho |
FP |
2-3E11 vg/animal |
RO |
3-4 weeks |
10.1016/j.celrep.2021.108754 |
163498 |
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, PVALB+ neurons |
eHGT_079h-minRho |
FP |
2-3E11 vg/animal |
RO |
3-4 weeks |
10.1016/j.celrep.2021.108754 |
163501 |
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, cortex, PVALB+ neurons, midbrain structures, deep cerebellar nuclei, and main olfactory bulb |
eHGT_082h-minRho |
FP |
2-3E11 vg/animal |
RO |
3-4 weeks |
10.1016/j.celrep.2021.108754 |
163502 |
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, PVALB+ neurons |
eHGT_140h-minRho |
FP |
2-3E11 vg/animal |
RO |
3-4 weeks |
10.1016/j.celrep.2021.108754 |
163503 |
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, PVALB+ neurons |
eHGT_359h-minRho |
FP |
2-3E11 vg/animal |
RO |
3-4 weeks |
10.1016/j.celrep.2021.108754 |
163504 |
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, cortex, PVALB+ neurons bias, SST+ neurons, cerebellar Purkinje cells, mid/hindbrain nuclei, hippocampus, and main olfactory bulb neurons |
eHGT_023h-minBG |
FP |
2-3E11 vg/animal |
RO |
3-4 weeks |
10.1016/j.celrep.2021.108754 |
163499 |
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, PVALB+ neurons bias, SST+ neurons |
eHGT_064h-minBG |
FP |
2-3E11 vg/animal |
RO |
3-4 weeks |
10.1016/j.celrep.2021.108754 |
163500 |
PHP.eB |
POS |
NHP, Macaca mulatta |
CNS, PVALB+ neurons |
eHGT_079h_minRho |
FP |
1-2E11 vg/site |
Intracranial (occipital) |
51-113 days |
10.1016/j.celrep.2021.108754 |
163501 |
PHP.eB |
POS |
NHP, Macaca nemestrina |
CNS, PVALB+ neurons |
eHGT_082h-minRho |
FP |
1-2E11 vg/site |
Intracranial (occipital) |
51-113 days |
10.1016/j.celrep.2021.108754 |
163502 |
PHP.eB |
POS |
NHP, Macaca mulatta |
CNS, PVALB+ neurons |
eHGT_128h-minRho |
FP |
1-2E11 vg/site |
Intracranial (occipital) |
51-113 days |
10.1016/j.celrep.2021.108754 |
163498 |
PHP.eB |
POS |
NHP, Macaca nemestrina |
CNS, PVALB+ neurons |
eHGT_359h-minRho |
FP |
1-2E11 vg/site |
Intracranial (occipital) |
51-113 days |
10.1016/j.celrep.2021.108754 |
163504 |
PHP.eB |
POS |
NHP, Macaca mulatta |
CNS, PVALB+ neurons |
eHGT_140h-minRho |
FP |
1-2E11 vg/site |
Intracranial (occipital) |
51-113 days |
10.1016/j.celrep.2021.108754 |
163503 |
PHP.eB |
POS |
NHP, Macaca mulatta |
CNS, PVALB+ neurons |
eHGT_140h-minRho |
FP |
1-2E11 vg/site |
Intracranial (temporal) |
51-113 days |
10.1016/j.celrep.2021.108754 |
163503 |
PHP.eB |
POS |
NHP, Macaca nemestrina |
CNS, PVALB+ neurons |
eHGT_140h-minRho |
FP |
1-2E11 vg/site |
Intracranial (somatosensory) |
51-113 days |
10.1016/j.celrep.2021.108754 |
163503 |
PHP.eB |
POS |
NHP, Macaca nemestrina |
CNS, PVALB+ neurons |
eHGT_140h-minRho |
FP |
1-2E11 vg/site |
Intracranial (motor) |
51-113 days |
10.1016/j.celrep.2021.108754 |
163503 |
PHP.eB |
POS |
NHP, Macaca nemestrina, temporal cortex brain slice culture |
CNS, L2–L6 excitatory neurons |
eHGT_078m-minBG |
FP |
2-3E10 vg/slice |
direct application to slice |
1-2 weeks |
10.1016/j.celrep.2021.108754 |
163508 |
PHP.eB |
POS |
NHP, Macaca nemestrina, temporal cortex brain slice culture |
CNS, L3–L5 pyramidal neurons |
eHGT_058h-minBG |
FP |
2-3E10 vg/slice |
direct application to slice |
1-2 weeks |
10.1016/j.celrep.2021.108754 |
163494 |
PHP.eB |
POS |
NHP, Macaca nemestrina, temporal cortex brain slice culture |
CNS, GAD1+ GABAergic neurons |
DLX2.0_minBG |
FP |
2-3E10 vg/slice |
direct application to slice |
1-2 weeks |
10.1016/j.celrep.2021.108754 |
163505 |
PHP.eB |
POS |
NHP, Macaca nemestrina, temporal cortex brain slice culture |
CNS, GAD1+ and PVALB+ low specificity |
eHGT_079h_minRho |
FP |
2-3E10 vg/slice |
direct application to slice |
1-2 weeks |
10.1016/j.celrep.2021.108754 |
163501 |
PHP.eB |
POS |
NHP, Macaca nemestrina, temporal cortex brain slice culture |
CNS, GAD1+ and PVALB+ low specificity |
eHGT_082h-minRho |
FP |
2-3E10 vg/slice |
direct application to slice |
1-2 weeks |
10.1016/j.celrep.2021.108754 |
163502 |
PHP.eB |
POS |
NHP, Macaca nemestrina, temporal cortex brain slice culture |
CNS, GAD1+ and PVALB+ low specificity |
eHGT_128h-minRho |
FP |
2-3E10 vg/slice |
direct application to slice |
1-2 weeks |
10.1016/j.celrep.2021.108754 |
163498 |
PHP.eB |
POS |
NHP, Macaca nemestrina, temporal cortex brainslice culture |
CNS, GAD1+ and PVALB+ low specificity |
eHGT_140h-minRho |
FP |
2-3E10 vg/slice |
direct application to slice |
1-2 weeks |
10.1016/j.celrep.2021.108754 |
163503 |
PHP.eB |
POS |
Human, temportal cortex brain slice culture |
CNS, GAD1+ inhibitory neurons |
hDLXI56i-minBG |
FP |
2-3E10 vg/slice |
direct application to slice |
8, 13, 28, and 69 days |
10.1016/j.celrep.2021.108754 |
163493 |
PHP.eB |
POS |
Human, temportal cortex brain slice culture |
CNS, GAD1+ inhibitory neurons |
DLX2.0_minBG |
FP |
2-3E10 vg/slice |
direct application to slice |
7, 7, 14, and 34 days |
10.1016/j.celrep.2021.108754 |
163505 |
PHP.eB |
POS |
Mouse, Ai14 |
CNS, cortex |
EF1a |
Recombinase, Cre |
4-8E10 vg/animal |
ICV |
2 weeks |
||
PHP.eB |
POS |
Mouse, Ai14 |
CNS, cortex |
EF1a |
Recombinase, Cre |
-- |
RO |
2 weeks |
||
PHP.eB |
POS |
Mouse, Ai66R |
CNS, cortex |
EF1a |
Recombinase, CDreV |
4-8E10 vg/animal |
ICV |
2 weeks |
||
PHP.eB |
POS |
Mouse, Ai66R |
CNS, cortex |
Syn |
Recombinase, NDreV |
4-8E10 vg/animal |
ICV |
2 weeks |
||
PHP.eB |
POS |
Mouse, Ai75 |
CNS, cortex |
EF1a |
Recombinase, iCreV |
4-8E10 vg/animal |
ICV |
|||
PHP.eB |
POS |
Mouse, Ai65F |
CNS, cortex |
EF1a |
Recombinase, iFlpV |
4-8E10 vg/animal |
ICV |
|||
PHP.eB |
POS |
Mouse, Rbp4-Cre |
CNS, cortex |
EF1a, FSF-FLEX |
FP |
1-2E10 vg/animal |
Intracranial (cortex) |
|||
PHP.eB |
POS |
Mouse, Rbp4-Cre |
CNS, cortex |
EF1a |
Recombinase, iFlpV |
1-2E10 vg/animal |
Intracranial (cortex) |
|||
PHP.eB |
POS |
Mouse, Sst-IRES-FlpO x Ai65 |
CNS, cortex, somatostatin-positive inhibitory interneurons |
EF1a |
Recombinase, iCreV |
-- |
RO |
|||
Cu64labeled-PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
1.5E10 vg/animal |
Tail vein |
3 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
1.5E10 vg/animal |
Tail vein |
3 weeks |
37825 |
|
Cu64labeled-PHP.eB |
POS |
Mouse, C57BL/6J |
CNS and spleen |
CAG |
FP |
1.5E10 vg/animal |
Tail vein |
4 hours |
||
Cu64labeled-PHP.eB |
POS |
Mouse, C57BL/6J |
CNS bias and spleen |
CAG |
FP |
1.5E10 vg/animal |
Tail vein |
21 hours |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, neurons |
hSyn1 |
FP |
3E11 vg/animal |
RO |
4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, astrocytes |
GFAP |
FP |
3E11 vg/animal |
RO |
4 weeks |
104053 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, oligodendrocytes |
MBP |
FP |
3E11 vg/animal |
RO |
4 weeks |
104054 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, neurons |
CAG miR-204TS |
FP |
1E11 vg/animal |
RO |
3 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, astrocytes |
CAG miR-708TS |
FP |
1E11 vg/animal |
RO |
3 weeks |
||
PHP.S |
POS |
Mouse, TH-IRES-Cre |
PNS, paravertebral ganglia |
CAG DIO |
FP |
1E12 vg/animal |
RO |
2 weeks |
104058 |
|
PHP.S |
POS |
Mouse, TH-IRES-Cre |
PNS, paravertebral ganglia |
hSyn1 |
FP |
1E12 vg/animal |
RO |
2 weeks |
99135 |
|
PHP.S |
POS |
Mouse, TRPV1-IRES-Cre |
PNS, nodose ganglion |
CAG DIO |
FP |
1E12 vg/animal |
RO |
3 weeks |
104052 |
|
PHP.S |
POS |
Mouse, TRPV1-IRES-Cre |
PNS, DRG |
CAG DIO |
FP |
3E12 vg/animal |
RO |
2 weeks |
104058, 104059 |
|
PHP.S |
POS |
Mouse, C57BL/6J |
PNS, duodenum, myenteric plexus, submucosal plexus |
mTH |
FP |
5E11 vg/animal |
RO |
3 weeks |
||
PHP.S |
POS |
Mouse, C57BL/6J |
PNS, duodenum, myenteric plexus, submucosal plexus |
hSyn |
FP |
5E11 vg/animal |
RO |
3 weeks |
104060 |
|
PHP.S |
POS |
Mouse, C57BL/6J |
Heart |
CAG |
FP |
1E12 vg/animal |
RO |
4 weeks |
104061 |
|
PHP.S |
POS |
Mouse, C57BL/6J |
Heart, cardiac muscle |
CAG |
FP |
1E12 vg/animal |
RO |
11 days |
99134, 99123, 99122 |
|
PHP.S |
POS |
Mouse, TRPV1-IRES-Cre |
PNS, cardiac nerves |
CAG DIO |
FP |
1E12 vg/animal |
RO |
3 weeks |
99133, 104058, 104059 |
|
PHP.S |
POS |
Mouse, ChAT-IRES-Cre |
PNS, cardiac ganglion |
Ef1a DIO |
ChR2, FP |
1E12 vg/animal |
RO |
3 weeks |
20298 |
|
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
1E12 vg/animal |
RO |
3 weeks |
99134 |
|
PHP.B |
POS |
Mouse, FVB/NCrl |
CNS, all |
CAG |
FP |
1E12 vg/animal |
RO |
3 weeks |
99134 |
|
PHP.B |
POS |
Mouse, 129S1/SvlmJ |
CNS, all |
CAG |
FP |
1E12 vg/animal |
RO |
3 weeks |
99134 |
|
PHP.B |
NEG |
Mouse, BALB/cJ |
CNS, all |
CAG |
FP |
1E12 vg/animal |
RO |
3 weeks |
99134 |
|
PHP.eB |
POS |
Mouse, 129T2/SvEmsJ |
CNS, all |
CAG |
FP |
3E11 vg/animal |
RO |
2 weeks |
||
PHP.eB |
POS |
Rat, Fischer |
CNS, all |
CAG |
FP |
3E12 vg/animal |
Tail vein |
3 weeks |
||
PHP.eB |
POS |
Rat, Long-Evans |
CNS, neurons, liver detarget |
CMV-hSyn1 miR122TS |
Sensor, GCaMP6f |
1E13 vg/animal |
Tail vein |
3 weeks |
||
PHP.B |
POS |
Mouse, FVB/NCrl |
CNS, neurons |
CaMKIIa |
Sensor, CaMPARI |
3E11 vg/animal |
RO |
2 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
Sensor, SPOTlight |
3E11 vg/animal |
RO |
2 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
2E11 vg/animal |
RO |
2 weeks |
||
PHP.S |
POS |
Mouse, Mrgpra3Cre; NmbrCre; RosaTdtf/+ |
PNS, spinal neurons |
CAG DIO |
Opsin, ChR2, FP |
7.5E10 vg/animal |
Intrathecal |
3 weeks |
||
PHP.B |
POS |
Rat, Sprague-Dawley, neonate |
CNS, all |
CBA |
FP |
1.9E12 vg/animal |
Facial vein |
4 weeks |
||
PHP.B |
POS |
Rat, Sprague-Dawley |
CNS, neurons |
Syn |
FP |
3.8E13 vg/kg |
RO or Tail vein |
4 weeks |
||
PHP.B |
POS |
Rat, Sprague-Dawley, neonate |
CNS, all |
CBA |
Disease model |
1.6E12 vg/animal |
Facial vein |
<10 days |
||
PHP.B |
POS |
Rat, Sprague-Dawley |
CNS, all |
CBA |
Disease model |
3E13 vg/kg |
RO or Tail vein |
2 weeks |
||
PHP.B |
POS |
Mouse, FRMD7tm1a(KOMP)Wtsi |
CNS, all |
EF1a |
Sensor, GCaMP6s |
1.7E12 vg/animal |
RO |
3 weeks |
||
PHP.B |
POS |
Mouse, BChE KO |
CNS, all |
Rescue |
1E13 vg/animal |
Tail vein |
3 weeks |
|||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, purkinje neurons |
L7-6 |
FP |
3E12 vg/animal |
RO |
3 weeks |
||
PHP.B |
POS |
Mouse, AβPPswe/PS-1 |
CNS, hippocampus |
IE4/5 |
Rescue |
Intracranial (hippocampus) |
2.5 weeks |
|||
PHP.B |
POS |
Mouse, AβPPswe/PS-1 |
CNS, hippocampus |
IE4/5 |
FP |
Intracranial (hippocampus) |
2.5 weeks |
|||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all, DRG, Sympathetic ganglia |
CBA |
FP |
2E12 vg/animal |
Tail vein |
3-5 weeks |
||
PHP.B |
POS |
Mouse, neonate |
CNS, all, Spinal cord |
CBA |
FP |
1.5E11 vg/animal |
Facial vein |
3 weeks |
||
PHP.B |
POS |
Mouse, Ai9 |
CNS, all |
CBA |
Recombinase, Cre |
1E9 - 1E12 vg/animal |
Tail vein |
|||
PHP.B |
POS |
Mouse, NeuroD6-Cre |
CNS, neurons cortex hippocampus |
CBA FLEX |
FP |
2E12 vg/animal |
Tail vein |
|||
PHP.B |
POS |
Mouse, PV-Cre |
CNS, gabaergic interneurons |
CBA FLEX |
FP |
2E12 vg/animal |
Tail vein |
|||
PHP.B |
POS |
Mouse, Dat-Cre |
CNS, dopaminergic neurons |
CBA FLEX |
FP |
2E12 vg/animal |
Tail vein |
|||
PHP.B |
POS |
Mouse, Olig2-Cre |
CNS, oligodendrocytes |
CBA FLEX |
FP |
2E12 vg/animal |
Tail vein |
|||
PHP.B |
POS |
Mouse, PV-Cre |
CNS, gabaergic interneurons |
Syn FLEX |
Chemogenetic DREADDM4, FP |
2E12 vg/animal |
Tail vein |
|||
PHP.B |
POS |
Mouse, Tsc1f/f |
CNS, all |
CBA |
Recombinase, Cre |
2E12 vg/animal |
Tail vein |
1 week |
||
PHP.B |
POS |
Mouse, Tsc1f/f |
CNS, all |
CBA |
Recombinase, Cre |
1E11 vg/animal |
Tail vein |
3 weeks |
||
PHP.B |
POS |
Mouse, A53T-SCNA |
CNS, all |
EF1a |
Rescue, FP |
2E12 vg/animal |
Tail vein |
3 - 5 months |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all, reduced periphery |
CBA |
FP |
2E12 vg/animal |
Carotid artery |
3 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
FP |
5E13 vg/kg |
|||||
PHP.B |
NEG |
Mouse, BALB/cJ |
CNS, all |
FP |
5E13 vg/kg |
|||||
PHP.B |
NEG |
NHP, rhesus macaque |
CNS, all |
FP |
7.5E13 vg/kg |
5 days |
||||
PHP.B |
NEG |
NHP, rhesus macaque |
CNS, all |
FP |
2E13 vg/kg |
3 weeks |
||||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
Sensor, GCaMP6s |
RO |
|||||
PHP.B |
NEG |
NHP, marmoset |
CNS, all |
CBh |
FP |
5E13 vg/kg |
femoral vein |
6 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CBh |
FP |
1E12 vg/animal |
RO |
4 weeks |
||
PHP.B |
POS |
Mouse, Rho+/P23H |
Retina |
CBA |
FP |
1E12 vg/animal |
Intravitreal |
2 weels |
||
PHP.B |
POS |
Mouse, Rho+/P23H |
Retina |
TetO |
CRISPR, SpCas9-VQR |
1E12 vg/animal |
Intravitreal |
2 weels |
||
PHP.B |
POS |
Mouse, Rho+/P23H |
Retina |
hRho |
CRISPR, sgRNA, Inducer |
1E12 vg/animal |
Intravitreal |
2 weels |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CBA self complimentary |
FP |
1E12 vg/animal |
Tail vein |
3 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CBA self complimentary |
FP |
2.5E12 vg/animal |
Tail vein |
3 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, neurons |
hSyn self complimentary |
FP |
2E11 vg/animal |
Tail vein |
3 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, neurons |
hSyn self complimentary |
FP |
1E12 vg/animal |
Tail vein |
3 weeks |
||
PHP.B |
POS |
Mouse, Gja10-Cre |
Retina |
Ef1a DIO |
Rescue |
3E14 vg/kg |
RO |
4-5 weeks |
||
PHP.B |
POS |
Mouse, Gja10Cre × PV-Flp × Flp-GFP-reporter |
Retina |
Ef1a DIO |
Rescue |
3E14 vg/kg |
RO |
4-5 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
Spinal cord |
hSyn |
Rescue |
1E12 vg/animal |
Tail vein |
8 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
Spinal cord |
hSyn |
FP |
1E12 vg/animal |
Tail vein |
8 weeks |
||
PHP.B |
POS |
Mouse, Chat-Cre |
Spinal cord |
hSyn FLEX |
Rescue |
1E12 vg/animal |
Tail vein |
8 weeks |
||
PHP.B |
POS |
Mouse, Vglut2-Cre |
Spinal cord |
hSyn FLEX |
Rescue |
1E12 vg/animal |
Tail vein |
8 weeks |
||
PHP.B |
POS |
Mouse, Vgat-Cre |
Spinal cord |
hSyn FLEX |
Rescue |
1E12 vg/animal |
Tail vein |
8 weeks |
||
PHP.B |
POS |
Mouse |
Cochlea neurons |
hSyn |
Opsin, Chronos |
1-2E9 vg/animal |
Cochlea |
4-12 weeks |
||
PHP.B |
POS |
Mouse, neonate |
Cochlea neurons |
hSyn |
Opsin, Chronos |
1-2E9 vg/animal |
Cochlea |
4-12 weeks |
||
PHP.eB |
POS |
Mouse, GFAP-mCAT |
CNS, astrocytes |
GFAP |
FP |
5E10 vg/animal |
RO |
3 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, neurons |
hSyn |
Sensor, GCaMP6s |
6E11 vg/animal |
Tail vein |
4-8 weeks |
||
PHP.eB |
POS |
Mouse, fos-cre −/− |
CNS, neurons |
hSyn |
Sensor, GCaMP6s |
6E11 vg/animal |
Tail vein |
4-8 weeks |
||
PHP.eB |
NEG |
Mouse, C57BL/6J |
Inner ear |
CAG |
FP |
3.6E9 vg/animal |
Round window membrane |
|||
PHP.eB |
POS |
Mouse, C57BL/6J aged |
CNS, oligodendrocytes |
CMV |
CRISPR, SpCas9 |
5E11 vg/animal |
Tail vein |
4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J neonate |
CNS, oligodendrocytes |
CMV |
CRISPR, SpCas9 |
5E10 vg/animal |
Tail vein |
4 weeks |
||
PHP.eB |
POS |
Mouse, Sim1-Cre |
CNS, neurons |
hSyn FLEX |
Recombinase, FLPo |
RO |
122503 |
|||
PHP.eB |
POS |
Mouse, Sim1-Cre |
CNS, neurons |
CAG FRT |
FP |
RO |
122504 |
|||
PHP.eB |
POS |
Mouse, AKR/J |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
|||
PHP.eB |
POS |
Mouse, C57L/J |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
|||
PHP.eB |
POS |
Mouse, DBA/J |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
|||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
|||
PHP.eB |
NEG |
Mouse, BALB/cJ |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
|||
PHP.eB |
POS |
Mouse, FVB/NJ |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
|||
PHP.eB |
POS |
Mouse, LP/J |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
|||
PHP.eB |
POS |
Mouse, MOLF/EiJ |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
|||
PHP.eB |
NEG |
Mouse, CAST/EiJ |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
|||
PHP.eB |
NEG |
Mouse, CBA/J |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
|||
PHP.eB |
NEG |
Mouse, NOD/ShiLtJ |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
|||
PHP.eB |
NEG |
Mouse, NZB/B1NJ |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
|||
PHP.eB |
NEG |
Mouse, PWK/PhJ |
CNS, all |
CAG |
FP |
1E11 vg/animal |
RO |
|||
PHP.eB |
POS |
Mouse, C57BL/6J aged |
CNS, all |
CAG |
FP |
4E11 vg/animal |
6-12 months |
|||
PHP.eB |
POS |
Mouse, C57BL/6J aged |
CNS, all |
CAG |
Rescue, FP |
4E11 vg/animal |
6-12 months |
|||
PHP.eB |
POS |
Mouse, C57BL/6N or 6J |
CNS, neurons |
NSE |
FP |
6.4E11 vg/animal |
RO |
1 month |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CBh |
Rescue, FP |
1-3E11 vg/animal |
RO |
3 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CBA self complimentary |
FP |
1E12 vg/animal |
Tail vein |
3 weeks |
10.3791/58960 |
|
PHP.B |
POS |
Mouse, GAAKO |
CNS, all |
CMV/CB |
Rescue |
5E12 vg/kg |
RO |
14 weeks |
||
PHP.B |
POS |
Mongolian gerbil |
Inner ear neurons |
hSyn |
Opsin, ChR2 CatCH |
1E10 vg/animal |
cochlea spiral ganglion |
4 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CB7 |
FP |
1E12 vg/animal |
Tail vein |
3 weeks |
||
PHP.B |
NEG |
Mouse, BALB/cJ |
CNS, all |
CB7 |
FP |
1E12 vg/animal |
Tail vein |
3 weeks |
||
PHP.B |
NEG |
Mouse, Ly6a-KO |
CNS, all |
CB7 |
FP |
1E12 vg/animal |
Tail vein |
3 weeks |
||
PHP.B |
POS |
Mouse, 129S1/SvlmJ |
CNS, all |
CB7 |
FP |
1E12 vg/animal |
Tail vein |
3 weeks |
||
PHP.B |
POS |
Mouse, DBA/2J |
CNS, all |
CB7 |
FP |
1E12 vg/animal |
Tail vein |
3 weeks |
||
PHP.B |
POS |
Mouse, FVB/NJ |
CNS, all |
CB7 |
FP |
1E12 vg/animal |
Tail vein |
3 weeks |
||
PHP.B |
NEG |
Mouse, C3H/HeJ |
CNS, all |
CB7 |
FP |
1E12 vg/animal |
Tail vein |
3 weeks |
||
PHP.B |
NEG |
Mouse, CBA/J |
CNS, all |
CB7 |
FP |
1E12 vg/animal |
Tail vein |
3 weeks |
||
PHP.B |
NEG |
Mouse, A/J |
CNS, all |
CB7 |
FP |
1E12 vg/animal |
Tail vein |
3 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, astrocytes |
GFAP |
FP |
1E12 vg/animal |
RO |
3 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, neurons |
rNSE |
FP |
1E12 vg/animal |
RO |
3 weeks |
||
PHP.B |
NEG |
Rat, Sprague-Dawley |
CNS |
FP |
4-5E13 vg/kg |
3 weeks |
||||
PHP.B |
NEG |
Mouse |
Inner ear |
CMV |
FP |
1E7 vg/animal |
Round window membrane |
3 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J neonate |
Inner ear |
CBA |
FP |
5E10 vg/animal |
Round window membrane |
5 days |
||
PHP.B |
POS |
Mouse, CD1 neonate |
Inner ear |
CBA |
FP |
5E10 vg/animal |
Round window membrane |
5 days |
||
PHP.B |
POS |
Mouse, Crln1−/− neonate |
Inner ear |
CBA |
Rescue |
7.4E10 vg/animal |
Round window membrane |
4 weeks |
||
PHP.B |
POS |
Mouse, Crln1−/− neonate |
Inner ear |
CBA |
Rescue |
1.8E11 vg/animal |
Round window membrane |
4 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
Retina |
CBA |
FP |
2.1E9 vg/animal |
subretinal |
8 days |
||
PHP.B |
NHP, cynologous monkey |
Inner ear |
CBA |
FP |
3E11 vg/animal |
Round window membrane |
7 weeks |
|||
PHP.B |
POS |
Mouse, C57BL/6J |
PNS, sciatic nerve |
CMV |
FP |
2E11 vg/animal |
Tail vein |
5 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
3E10 vg/animal |
jugular vein |
|||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
3E10 vg/animal |
Carotid artery |
|||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
3E10 vg/animal |
lateral ventricle |
|||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
3E10 vg/animal |
intrathecal, cisterna magna |
|||
PHP.B |
NEG |
NHP, rhesus macaque juvenile |
CNS, all |
CAG |
FP |
1E12 vg/kg |
Carotid artery |
|||
PHP.B |
NEG |
NHP, rhesus macaque juvenile |
CNS, all |
CAG |
FP |
1E12 vg/kg |
intrathecal, cisterna magna |
|||
PHP.eB |
POS |
Mouse, C3H/He-C57BL/6 hybrid |
CNS, all, Retina |
CAG |
FP |
3.3E9 vg/animal |
Tail vein |
3 weeks |
doi:10.7150/thno.42611 |
|
PHP.eB |
POS |
Mouse, Meg+/+, 129/svJ background |
CNS, all |
CAG |
FP |
5E10 vg/animal |
Tail vein |
3 weeks |
37825 |
|
PHP.eB |
POS |
Mouse, Meg+/-, 129/svJ background |
CNS, all |
CAG |
FP |
5E10 vg/animal |
Tail vein |
3 weeks |
37825 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
EF1a |
Opsin, LINuS |
2E11 vg/animal |
RO |
2 weeks |
||
PHP.eB |
POS |
Mouse, Fah−/−/Rag2−/−/Il2rg−/− (FRG) |
CNS, all |
CMV |
FP |
3.3E9 vg/animal |
Tail vein |
7 days |
||
PHP.B |
POS |
Mouse, B6/C3H neonate |
CNS, all |
CAG |
FP |
1.5E8 vg/site |
ICV |
30 days |
||
PHP.eB |
POS |
Mouse, B6/C3H neonate |
CNS, all |
CAG |
FP |
3.6E8 vg/site |
ICV |
30 days |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CBA-iMecp2 |
Rescue |
1E11 vg/animal |
Tail vein |
up to 15 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CBA-iMecp2 |
Rescue |
1E12 vg/animal |
Tail vein |
up to 15 weeks |
||
PHP.eB |
NEG |
Mouse, Mecp2-/y |
CNS, all |
CBA-iMecp2 |
Rescue |
1E9 vg/animal |
Tail vein |
up to 12 weeks |
||
PHP.eB |
POS |
Mouse, Mecp2-/y |
CNS, all |
CBA-iMecp2 |
Rescue |
1E10 vg/animal |
Tail vein |
up to 12 weeks |
||
PHP.eB |
POS |
Mouse, Mecp2-/y |
CNS, all |
CBA-iMecp2 |
Rescue |
1E11 vg/animal |
Tail vein |
up to 12 weeks |
||
PHP.eB |
POS |
Mouse, Mecp2-/y |
CNS, all |
CBA-iMecp2 |
Rescue |
1E12 vg/animal |
Tail vein |
up to 12 weeks |
||
PHP.eB |
NEG |
Mouse, Mecp2-/y |
CNS, all |
CBA |
FP |
1E9 vg/animal |
Tail vein |
up to 12 weeks |
||
PHP.eB |
POS |
Mouse, Mecp2-/y |
CNS, all |
CBA |
FP |
1E10 vg/animal |
Tail vein |
up to 12 weeks |
||
PHP.eB |
POS |
Mouse, Mecp2-/y |
CNS, all |
CBA |
FP |
1E11 vg/animal |
Tail vein |
up to 12 weeks |
||
PHP.eB |
POS |
Mouse, Mecp2-/y |
CNS, all |
CBA |
FP |
1E12 vg/animal |
Tail vein |
up to 12 weeks |
||
PHP.eB |
POS |
Mouse, Mecp2+/- |
CNS, all |
CBA-iMecp2 |
Rescue |
1E11 vg/animal |
Tail vein |
up to 15 months |
||
PHP.eB |
POS |
Mouse, Mecp2+/- |
CNS, all |
CBA |
FP |
1E11 vg/animal |
Tail vein |
up to 15 months |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, spinal cord sciatic neurons |
Syn |
Rescue, FP |
6E11 vg/animal |
Tail vein |
3 days or 4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, spinal cord sciatic neurons |
Syn |
FP |
6E11 vg/animal |
Tail vein |
3 days or 4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, striatum astrocytes |
GFAP |
CRISPR, CasRx, sgRNA |
1-3E10 vg/site |
Intracranial (striatum) |
1 week, 1 month, 3 months |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, striatum astrocytes |
GFAP |
CRISPR, CasRx |
1-3E10 vg/site |
Intracranial (striatum) |
1 week, 1 month, 3 months |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, striatum astrocytes |
GFAP |
FP |
1-3E10 vg/site |
Intracranial (striatum) |
1 week, 1 month, 3 months |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
Retina, astrocytes |
GFAP |
CRISPR, CasRx, sgRNA |
1E10 vg/site |
subretinal |
2-3 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
Retina, astrocytes |
GFAP |
CRISPR, CasRx |
1E10 vg/site |
subretinal |
2-3 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
Retina, astrocytes |
GFAP |
FP |
1E10 vg/site |
subretinal |
2-3 weeks |
||
PHP.eB |
POS |
Mouse, Ai9 |
Retina, astrocytes |
GFAP |
CRISPR, CasRx, sgRNA |
1E10 vg/site |
subretinal |
2-3 weeks, 1 month |
||
PHP.eB |
POS |
Mouse, Ai9 |
Retina, astrocytes |
GFAP |
CRISPR, CasRx |
1E10 vg/site |
subretinal |
2-3 weeks, 1 month |
||
PHP.eB |
POS |
Mouse, Ai9 |
Retina, astrocytes |
GFAP |
FP |
1E10 vg/site |
subretinal |
2-3 weeks, 1 month |
||
PHP.eB |
POS |
Mouse, Hdac1 cKO aged |
CNS, neurons |
shRNA, FP |
Intracranial (hippocampus) |
3 weeks |
||||
PHP.eB |
NEG |
Mouse, C57BL/6J neonate |
CNS, neurons |
Syn |
Sensor, GCaMP6s |
8E10 vg/site |
transverse sinus |
5 days - 3 weeks |
100843 |
|
PHP.eB |
POS |
Mouse |
CNS, neurons, retina |
CAG FLEX |
Inducer, tTA2 |
RO |
3 weeks |
DOI: 10.1126/science.aaz5887 |
||
PHP.eB |
POS |
Mouse, CaMKIIa-Cre |
CNS, neurons |
hSyn DIO |
FP |
1.3E11 vg/animal |
RO |
3 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, neurons, spinal cord |
LAP1 |
FP |
4E11 vg/animal |
RO |
30 days, 190 days |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, neurons, spinal cord |
LAP2 |
FP |
4E11 vg/animal |
RO |
30 days, 190 days |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, neurons, spinal cord |
LAP1_2 |
FP |
4E11 vg/animal |
RO |
30 days, 190 days |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all, spinal cord |
EF1a |
FP |
4E11 vg/animal |
RO |
30 days, 190 days |
||
PHP.eB |
POS |
Mouse, floxed-dCas9-VPRVPR/+/Vgat-CreCre/+/Scn1aRX/+ |
CNS, parvalbumin gabaergic neurons |
4x U6 |
CRISPRa, sgRNA |
1.8E11 vg/animal |
Tail vein |
8 weeks |
43860 |
|
PHP.eB |
POS |
Mouse, Klb-CRE |
CNS, hypothalamus |
CAG FLEX |
FP |
RO |
4 weeks |
28306 |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, parvalbumin neurons |
E2 |
FP |
1E12 vg/animal |
RO |
3 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, parvalbumin neurons |
Dlx |
FP |
1E12 vg/animal |
RO |
3 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, parvalbumin neurons |
E2 |
FP |
1E12 vg/animal |
RO |
1 week |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, parvalbumin neurons |
E2 |
Chemogenetic PSAM4-5HT3-LC |
1E12 vg/animal |
RO |
4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, parvalbumin neurons, upper cortex layers |
E11 |
FP |
1E12 vg/animal |
RO |
3 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, parvalbumin neurons, upper cortex layers |
E14 |
FP |
1E12 vg/animal |
RO |
3 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, parvalbumin neurons cortex |
E22 |
FP |
1E12 vg/animal |
RO |
3 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, parvalbumin neurons global |
E29 |
FP |
1E12 vg/animal |
RO |
3 weeks |
||
PHP.eB |
POS |
Rat, Sprague-Dawley |
CNS, parvalbumin neurons |
E2 |
FP |
Intracranial (cortex) |
||||
PHP.eB |
NHP, rhesus macaque |
CNS, parvalbumin neurons |
E2 |
FP |
Intracranial (cortex) |
|||||
PHP.eB |
POS |
Mouse, PV-Cre |
CNS, parvalbumin neurons |
Brainbow |
FP |
2E12 vg/animal |
RO |
3-4 weeks |
||
PHP.eB |
POS |
Human Organoid |
F49B7 Retinal organoid |
EF1a |
Sensor, GCaMP6s |
1.3E11 vg/organoid |
Direct application to tissue |
3-4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, brainstem serotonergic neurons |
TPH2 |
Opsin, ChRmine, FP |
4E11 vg/animal |
RO |
6 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, purkinje neurons |
L7 |
Opsin, ChRmine, FP |
4E11 vg/animal |
RO |
2 months |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, purkinje neurons |
L7 |
Opsin, ChRmine, FP |
Intracranial |
2 weeks |
|||
PHP.eB |
POS |
Mouse, CD1 |
CNS, neurons |
hSyn1 |
FP |
RO |
||||
PHP.eB |
POS |
Mouse, CD1 |
CNS, astrocytes |
GfaBC1D |
FP |
RO |
||||
PHP.eB |
POS |
Mouse, Flex-tdTomato |
CNS, astrocytes |
GfaBC1D |
CRISPR, Cas9 |
RO |
3 weeks |
|||
PHP.eB |
POS |
Mouse, Flex-tdTomato |
CNS, astrocytes |
GfaBC1D |
CRISPR, sgRNA, Recombinase, Cre |
RO |
3 weeks |
|||
PHP.eB |
POS |
Mouse, CD1 |
CNS, astrocytes |
GfaBC1D |
Chemogenetic, Split TurboID |
RO |
4 weeks |
|||
PHP.eB |
POS |
Mouse, CD1 |
CNS, neurons |
hSyn1 |
Chemogenetic, Split TurboID |
RO |
4 weeks |
|||
PHP.eB |
POS |
Mouse, CD1 |
CNS, astrocytes |
GfaBC1D |
Chemogenetic, TurboID |
RO |
4 weeks |
|||
PHP.eB |
POS |
Mouse, PV-Cre |
CNS, all |
CBh |
FP |
1E11 vg/animal |
RO |
3 weeks |
||
PHP.eB |
POS |
Mouse, PV-Cre |
CNS, all |
Ef1a DIO |
FP, cSNAIL |
4E11 vg/animal |
RO |
3-5 weeks |
160141 |
|
PHP.eB |
POS |
Mouse, Pvalb-2A-Cre Ai14 |
CNS, all |
Ef1a DIO |
FP, cSNAIL |
4E11 vg/animal |
RO |
3-5 weeks |
160141 |
|
PHP.eB |
NEG |
Mouse, C57BL/6J neonate |
CNS, all |
CB7 |
FP |
1E10 vg/animal |
ICV |
30 days |
||
PHP.eB |
NEG |
Mouse, C57BL/6J |
CNS, olfactory bulb |
CB7 |
FP |
1E11 vg/animal |
Intranasal |
30 days |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CB7 |
FP |
1E11 vg/animal |
Tail vein |
30 days |
||
PHP.eB |
NEG |
Mouse, B6C3 |
CNS, all |
CB7 |
FP |
1E11 vg/animal |
Tail vein |
30 days |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CB7, self complementary |
FP |
1E11 vg/animal |
Tail vein |
30 days |
||
PHP.S |
POS |
Mouse, C57BL/6J |
PNS, DRG neurons |
hSyn |
Chemogenetic, hM4D(Gi) |
5E11 vg/site |
Knee, intraarticular |
3-4 weeks |
50475 |
|
PHP.S |
POS |
Mouse, C57BL/6J |
PNS, DRG neurons |
hSyn |
Chemogenetic, hM3D(Gq) |
5E11 vg/site |
Knee, intraarticular |
3-4 weeks |
50474 |
|
PHP.S |
POS |
Mouse, C57BL/6J |
PNS, DRG neurons |
CAG |
FP |
3E11 vg/site |
Knee, intraarticular |
3-4 weeks |
||
PHP.S |
POS |
Mouse, C57BL/6J |
PNS, DRG neurons |
CAG |
FP |
1E12 vg/site |
Knee, intraarticular |
3-4 weeks |
||
PHP.S |
POS |
Mouse, C57BL/6J |
PNS, DRG sensory neurons |
U6 |
shRNA |
5E9 - 5E10 vg/animal |
Intrathecal, lumbar |
12 weeks |
85741 |
|
PHP.S |
NEG |
Mouse, Swiss-Webster |
PNS, trigeminal neurons, superior cervical ganglia |
CBh |
FP |
1E12 vg/animal |
RO |
3 weeks |
||
PHP.S |
POS |
Mouse, C57BL/6J |
PNS, Enteric plexus |
hSyn |
Inducer, tTA2 |
2.5E9 - 1E11 vg/animal |
RO |
3 weeks |
99120 |
|
PHP.S |
POS |
Mouse, C57BL/6J |
PNS, Enteric plexus |
TRE |
FP |
1E12 vg/animal |
RO |
3 weeks |
99131, 99114, 99113 |
|
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CBA |
FP |
1E12 vg/animal |
Tail vein |
3 weeks |
||
PHP.B |
NEG |
Mouse, BALB/cJ |
CNS, all |
CBA |
FP |
1E12 vg/animal |
Tail vein |
3 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CBA |
FP |
5E10 vg/animal |
ICV |
|||
PHP.B |
NEG |
Mouse, BALB/cJ |
CNS, all |
CBA |
FP |
5E10 vg/animal |
ICV |
|||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CMV |
FP |
1E11 vg/animal |
RO |
3 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CMV |
CRISPR, split intein CBE |
4E12 vg/animal |
RO |
3-4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CBh |
FP |
2E11 vg/animal |
RO |
3-4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J neonate |
CNS, all |
CBh |
CRISPR, split intein CBE |
4E10 vg/animal |
ICV |
3-4 weeks |
137176, 137175 |
|
PHP.eB |
POS |
Mouse, C57BL/6J neonate |
CNS, all |
CBh |
FP |
1E10 vg/animal |
ICV |
3-4 weeks |
||
PHP.B |
POS |
Mouse, Rhodopsin-Cre Ai9 |
Retina |
CBh |
CRISPR, split intein CBE |
5E9 vg/site |
subretinal |
3-4 weeks |
137176, 137175 |
|
PHP.B |
POS |
Mouse, Rhodopsin-Cre Ai9 |
Retina |
CBh |
FP |
5E9 vg/site |
subretinal |
3-4 weeks |
||
PHP.eB |
POS |
Mouse, Npc1I1061T (c.3182T > C) neonate |
CNS, all |
CBh |
CRISPR, split intein CBE |
3E12 vg/animal |
RO |
up to 100 days |
137176, 137175 |
|
PHP.B |
POS |
Mouse, B6/129S neonate |
CNS, all |
CMV |
FP |
2E11 vg/animal |
temporal facial vein |
2 weeks |
||
PHP.B |
POS |
Mouse, B6/129S-Fdxrm1J Otop3m1J/GrsrJ neonate |
CNS, all |
CMV |
Rescue |
2E11 vg/animal |
temporal facial vein |
up to 4 months |
||
PHP.B |
POS |
Mouse, Hexb−/− |
CNS, all |
BiCBA |
Rescue |
1E12 vg/animal |
Tail vein |
up to 600 days |
||
PHP.B |
POS |
Mouse, Hexb−/− |
CNS, all |
BiCBA |
Rescue |
3E11 vg/animal |
Tail vein |
up to 600 days |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CMV |
FP |
3E11 vg/animal |
Tail vein |
3 weeks |
||
PHP.eB |
NEG |
Mouse, Apoe-/- |
CNS, all |
CMV |
FP |
3E11 vg/animal |
Tail vein |
3 weeks |
||
PHP.eB |
NEG |
Mouse, Ldlr-/- |
CNS, all |
CMV |
FP |
3E11 vg/animal |
Tail vein |
3 weeks |
||
PHP.eB |
NEG |
Mouse, BALB/cJ |
CNS, all |
CMV |
FP |
3E11 vg/animal |
Tail vein |
3 weeks |
||
PHP.eB |
POS |
Mouse, C57xBALB Ldlr+/- |
CNS, all |
CMV |
FP |
3E11 vg/animal |
Tail vein |
3 weeks |
||
PHP.eB |
POS |
Mouse, CAS9+/− fetus |
CNS, excitatory neurons |
CBh |
FP |
5E9 - 1E10 vg/animal |
In utero injection |
3 weeks |
||
PHP.eB |
POS |
Mouse, CAS9+/− fetus |
CNS, excitatory neurons |
CBh |
CRISPR, sgRNA, FP |
5E9 - 1E10 vg/animal |
In utero injection |
3 weeks |
91947 |
|
PHP.eB |
POS |
Mouse, C57BL/6J neonate |
CNS, all |
CBA |
FP |
2E11 vg/animal |
ICV |
5-6 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J [B6J.129(Cg)-Igs2tm1.1(CAG-cas9*)Mmw/J |
CNS, all |
CBA |
FP, CRISPR, sgRNA |
2E11 vg/animal |
ICV |
5-6 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J [B6J.129(Cg)-Igs2tm1.1(CAG-cas9*)Mmw/J |
CNS, all |
CBA |
FP, CRISPR, sgRNA |
2E11 vg/animal |
ICV |
5-6 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J [B6J.129(Cg)-Igs2tm1.1(CAG-cas9*)Mmw/J |
CNS, all |
CBA |
FP, CRISPR, sgRNA |
5E10 vg/animal |
ICV |
5-6 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J [B6J.129(Cg)-Igs2tm1.1(CAG-cas9*)Mmw/J |
CNS, all |
CBA |
FP, CRISPR, sgRNA |
2E11 vg/animal |
ICV |
5-6 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
2.5E11 vg/animal |
Tail vein |
4-6 weeks |
||
AAV5-PHP.B |
NEG |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
2.5E11 vg/animal |
Tail vein |
4-6 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
miRNA |
1E11 vg/site |
Intracranial (striatum) |
4-6 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
miRNA |
4E12 vg/animal |
Tail vein |
4-6 weeks |
||
PHP.B |
POS |
Mouse, Ube3am−/p+ neonate |
CNS, neurons |
hSyn |
Rescue |
1.6E11 vg/animal |
ICV |
10-14 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, neurons |
hSyn |
Rescue |
1.6E11 vg/animal |
ICV |
10-14 weeks |
||
PHP.B |
POS |
Mouse, 5xFAD |
CNS, neurons |
hSyn |
Rescue |
6.25E13 vg/kg |
Tail vein |
2 weeks - 12 months |
||
PHP.B |
POS |
Mouse, 5xFAD |
CNS, neurons |
hSyn |
FP |
6.25E13 vg/kg |
Tail vein |
2 weeks - 12 months |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, neurons |
hSyn |
Rescue |
6.25E13 vg/kg |
Tail vein |
1,3,6 months |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, neurons |
hSyn |
FP |
6.25E13 vg/kg |
Tail vein |
1,3,6 months |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, neurons |
hSyn |
Rescue |
3.12E13 vg/kg |
Tail vein |
1,3,6 months |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, neurons |
hSyn |
Rescue |
1.25E14 vg/kg |
Tail vein |
1,3,6 months |
||
PHP.B |
POS |
Mouse, Grin1flox/flox |
CNS, astrocytes |
GfaBC1D |
Sensor, GCaMP3 |
1.4E11 vg/animal |
RO |
3 weeks |
DOI: 10.1126/sciadv.abk1378 |
|
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, astrocytes |
GfaBC1D |
Sensor, GCaMP3 |
1.4E11 vg/animal |
RO |
3 weeks |
DOI: 10.1126/sciadv.abk1378 |
|
PHP.B |
POS |
Mouse, AppNL-G-F |
CNS, all |
CAG |
Rescue |
1E12 vg/animal |
Tail vein |
12 months |
||
PHP.B |
POS |
Mouse, C57BL/6J neonate |
Cochlea neurons |
hSyn |
Sensor, vf-Chrimson |
8.7E9 vg/animal |
scala tympani |
|||
PHP.eB |
POS |
Mouse, C57BL/6J neonate |
Cochlea neurons |
hSyn |
Sensor, vf-Chrimson-ES/TS |
1.1E10 vg/animal |
scala tympani |
|||
PHP.B |
POS |
Mouse, VGAT)-tdTomato |
CNS, neurons |
CBh |
FP |
2E11 vg/animal |
RO |
2 weeks |
||
PHP.eB |
POS |
Mouse, VGAT)-tdTomato |
CNS, neurons |
mCaMKII |
FP |
2E11 vg/animal |
RO |
2 weeks |
||
PHP.eB |
POS |
Mouse, VGAT)-tdTomato |
CNS, neurons |
SynI-mCMV |
FP |
2E11 vg/animal |
RO |
2 weeks |
||
PHP.eB |
POS |
Mouse, VGAT)-tdTomato |
CNS, neurons |
NSE |
FP |
2E11 vg/animal |
RO |
2 weeks |
||
PHP.eB |
POS |
Mouse, VGAT)-tdTomato |
CNS, neurons |
CBh |
FP |
2E11 vg/animal |
RO |
2 weeks |
||
PHP.eB |
POS |
Mouse, KO ARSA |
CNS, all |
CAG |
Rescue |
5E11 vg/animal |
RO |
3 months |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, neurons |
Syn1 |
FP |
3E11 vg/animal |
ICV |
4 weeks |
||
PHP.B |
NHP, rhesus macaque |
CNS, neurons |
Syn1 |
FP |
2-4E12 vg/kg |
ICV |
4-4.5 weeks |
|||
PHP.eB |
Cat |
CNS, all |
CAG |
FP |
5E8 vg/site |
Intracranial (cortex) |
7 days |
|||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
5E8 vg/site |
Intracranial (cortex) |
|||
PHP.eB |
NHP, rhesus macaque |
CNS, all |
CAG |
FP |
2E9 vg/site |
Intracranial (cortex) |
7 days |
|||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CMV |
FP |
4.8E9 vg/site |
Intracranial (anterior cingulate, cortex, cerebellum) |
30 days |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
X on |
FP |
2E12 vg/animal |
RO |
4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
X on |
Rescue |
2E12 vg/animal |
RO |
4 weeks |
||
PHP.eB |
NHP, macaca nemestrina |
CNS, parvalbumin neurons |
3xSP10ins-eHGT_359h-minRho* |
FP |
5E10 vg/site |
Intracranial (cortex) |
64 days |
163504 |
||
PHP.eB |
NHP, macaca nemestrina |
CNS, cortex L5 neurons |
eHGT_453m-minBglobin |
FP |
5E10 vg/site |
Intracranial (cortex) |
113 days |
164453 |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, astrocytes |
GFAP |
Sensor, iGlow |
7E9 vg/site |
Intracranial (hippocampus) |
2 weeks |
||
PHP.eB |
POS |
Mouse, Scn2agt/gt |
CNS, all |
EF1a |
Recombinase, FLPo, FP |
2E11 vg/animal |
Tail vein |
3 weeks |
||
PHP.eB |
POS |
Mouse, Scn2agt/gt |
CNS, all |
EF1a |
FP |
2E11 vg/animal |
Tail vein |
3 weeks |
||
PHP.eB |
POS |
Mouse, Scn2agt/gt |
CNS, all |
EF1a |
Recombinase, FLPo, FP |
5E7 vg/site |
Intracranial (striatum) |
3 weeks |
||
PHP.eB |
POS |
Mouse, Scn2agt/gt |
CNS, all |
EF1a |
FP |
5E7 vg/site |
Intracranial (striatum) |
3 weeks |
||
PHP.eB |
POS |
Mouse, Cabp2–/– neonate |
Cochlea |
hCMV hBA |
Rescue, FP |
8E9 vg/site |
scala tympani |
5-8 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
5E12 vg/animal |
Tail vein |
4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
5E11 vg/animal |
Tail vein |
4 weeks |
||
PHP.eB |
NEG |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
5E10 vg/animal |
Tail vein |
4 weeks |
||
PHP.eB |
NEG |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
5E9 vg/animal |
Tail vein |
4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, neurons |
CamKIIa |
FP |
5E12 vg/animal |
Tail vein |
4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, neurons |
hSyn1 |
FP |
5E12 vg/animal |
Tail vein |
4 weeks |
||
PHP.eB |
NHP, macaca fascicularis |
CNS, all |
CBA |
FP |
9E9 vg/site |
Intracranial (putamen) |
28 - 30 days |
|||
PHP.eB |
NHP, macaca fascicularis |
CNS, all |
CBA |
FP |
3.2E11 vg/animal |
ICV |
28 - 30 days |
|||
PHP.eB |
NHP, macaca fascicularis |
CNS, all |
CBA |
FP |
3.2E11 vg/animal |
ICM |
28 - 30 days |
|||
PHP.eB |
NHP, macaca fascicularis |
CNS, all |
CBA |
FP |
3.2E11 vg/animal |
Intrathecal, lumbar |
28 - 30 days |
|||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CB7 |
FP |
1E12 vg/animal |
Tail vein |
3 weeks |
||
AAV1-PHP.B |
NEG |
Mouse, C57BL/6J |
CNS, all |
CB7 |
FP |
1E12 vg/animal |
Tail vein |
3 weeks |
||
PHP.B |
POS |
Mouse, Rosa26-Cas9 knockin |
CNS, all |
4x U6 |
CRISPR, sgRNA |
6E9 vg/animal |
RO |
2 months |
||
PHP.eB |
POS |
Mouse, Ndufs4-/- |
CNS, all |
EF1a |
Rescue |
6E12 vg/animal |
RO |
up to 280 days |
||
PHP.eB |
POS |
Mouse, Ndufs4-/- |
CNS, all |
EF1a |
FP |
6E12 vg/animal |
RO |
up to 280 days |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, neurons |
Syn |
Sensor, GCaMP6s |
IV |
||||
PHP.B |
NEG |
Mouse, TgCRND8 |
CNS, cortex, striatum, thalamus |
smCBA |
FP |
1E11 vg/animal |
Tail vein, focused ultrasound FUS |
3 weeks |
||
PHP.B |
Mouse, TgCRND8 |
CNS, cortex, striatum, thalamus |
smCBA |
FP |
1E10 vg/animal |
Tail vein, focused ultrasound FUS |
3 weeks |
|||
PHP.B |
NEG |
Mouse, BALB/cJ |
CNS, cortex, striatum |
smCBA |
FP |
1E11 vg/animal |
Tail vein, focused ultrasound FUS |
3 weeks |
||
PHP.eB |
NEG |
Mouse, C57BL/6J |
Ef1a DIO |
FP, cSNAIL |
4E11 vg/animal |
RO |
3-4 weeks |
|||
PHP.eB |
POS |
Mouse, Pvalb-Cre |
CNS, parvalbumin neurons |
Ef1a DIO |
FP, cSNAIL |
4E11 vg/animal |
RO |
3-4 weeks |
||
PHP.eB |
POS |
Mouse, Sst-Cre |
CNS, somatostatin neurons |
Ef1a DIO |
FP, cSNAIL |
4E11 vg/animal |
RO |
3-4 weeks |
||
PHP.eB |
POS |
Mouse, Drd1-Cre |
CNS, dopaminergic neurons |
Ef1a DIO |
FP, cSNAIL |
4E11 vg/animal |
RO |
3-4 weeks |
||
PHP.eB |
POS |
Mouse, Adora2a-Cre |
CNS, stiatopallidal neurons |
Ef1a DIO |
FP, cSNAIL |
4E11 vg/animal |
RO |
3-4 weeks |
||
PHP.B |
NHP, rhesus macaque |
CNS, all |
CAG |
FP |
1E12 vg/animal |
Intrathecal, lumbar |
2 months |
|||
PHP.eB |
NHP, rhesus macaque |
CAG |
FP |
1E12 vg/animal |
Intrathecal, lumbar |
2 months |
||||
PHP.eB |
POS |
Mouse, UCP1-Cre |
CNS, hypothalamus |
FP |
8E10 vg/animal |
RO |
4 weeks |
|||
PHP.eB |
POS |
Mouse, Oxtr 1×PA-iCre/+ |
CNS, Oxtr neurons |
CBh FLEX |
FP |
2.5E11 vg/animal |
RO |
4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, spinal cord neurons |
hSyn |
Rescue, FP |
3E11 vg/animal |
Intrathecal, lumbar |
12 weeks |
||
PHP.S |
POS |
Mouse, C57BL/6J |
PNS, DRG neurons |
hSyn |
Rescue, FP |
3E11 vg/animal |
Intrathecal, lumbar |
12 weeks |
||
PHP.eB |
POS |
Mouse, Sarm1 KO |
CNS, spinal cord neurons |
hSyn |
Rescue, FP |
3E11 vg/animal |
Intrathecal, lumbar |
12 weeks |
||
PHP.S |
POS |
Mouse, Sarm1 KO |
PNS, DRG neurons |
hSyn |
Rescue, FP |
3E11 vg/animal |
Intrathecal, lumbar |
12 weeks |
||
PHP.eB |
POS |
Mouse, fosGFP |
CNS, S1 neurons |
Sensor, RCaMP1.07 |
1E9 vg/site |
Intracranial (cortex) |
1 week |
DOI: 10.1126/science.abl5981 |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, S1 neurons |
Sensor, RCaMP1.07 |
1E9 vg/site |
Intracranial (cortex) |
1 week |
DOI: 10.1126/science.abl5981 |
||
PHP.eB |
POS |
Mouse, Thy1-Cre |
CNS, S1 neurons |
hSyn DIO |
FP, Rescue, Retrograde tracing |
Intracranial (cortex) |
3 weeks |
|||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, S1 neurons |
hSyn |
FP, Rescue, Retrograde tracing |
Intracranial (cortex) |
3 weeks |
|||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, neurons |
hSyn |
FP, Rescue, Retrograde tracing |
4E11 vg/animal |
IV |
3 weeks |
||
PHP.eB |
POS |
Mouse, VGAT-Cre |
CNS, GABAergic neurons |
hSyn DIO |
FP, Rescue, Retrograde tracing |
4E11 vg/animal |
IV |
3 weeks |
||
PHP.eB |
POS |
Mouse, VGAT-Cre |
CNS, GABAergic neurons |
hSyn |
FP, Rescue, Retrograde tracing |
4E11 vg/animal |
IV |
3 weeks |
||
PHP.eB |
POS |
Mouse, Z-Q175-KI |
CNS, striatum astrocytes |
GfaBS1D |
FP, Rescue |
1E9 vg/site |
Intracranial (striatum) |
3-5 weeks |
||
PHP.eB |
POS |
Mouse, Z-Q175-KI |
CNS, astrocytes |
GfaBS1D |
FP, Rescue |
2-4E11 vg/animal |
IV |
|||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, endothelial pericytes |
CAG |
FP |
4E11 vg/animal |
RO or tail vein |
2 weeks |
DOI: 10.1126/science.abm4459 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, endothelial pericytes |
CAG |
FP, Rescue |
4E11 vg/animal |
RO or tail vein |
2 weeks |
DOI: 10.1126/science.abm4459 |
|
PHP.eB |
POS |
Mouse, C57BL/6J neonate |
CNS, endothelial pericytes |
CAG |
FP |
4E10 vg/animal |
RO or tail vein |
3 weeks |
DOI: 10.1126/science.abm4459 |
|
PHP.eB |
POS |
Mouse, C57BL/6J neonate |
CNS, endothelial pericytes |
CAG |
FP, Rescue |
4E10 vg/animal |
RO or tail vein |
3 weeks |
DOI: 10.1126/science.abm4459 |
|
PHP.eB |
POS |
Mouse, BAT-GAL |
CNS, endothelial pericytes |
CAG |
FP |
4E11 vg/animal |
RO or tail vein |
2 weeks |
DOI: 10.1126/science.abm4459 |
|
PHP.eB |
POS |
Mouse, BAT-GAL |
CNS, endothelial pericytes |
CAG |
FP, Rescue |
4E11 vg/animal |
RO or tail vein |
2 weeks |
DOI: 10.1126/science.abm4459 |
|
PHP.eB |
POS |
Mouse, BAT-GAL |
CNS, endothelial pericytes |
CAG |
FP |
4E10 vg/animal |
RO or tail vein |
3 weeks |
DOI: 10.1126/science.abm4459 |
|
PHP.eB |
POS |
Mouse, BAT-GAL |
CNS, endothelial pericytes |
CAG |
FP, Rescue |
4E10 vg/animal |
RO or tail vein |
3 weeks |
DOI: 10.1126/science.abm4459 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, neurons |
hSyn DIO, fDIO |
FP |
1E10 vg/animal |
RO |
18 days |
55650 |
|
PHP.eB |
POS |
Mouse, Crabp1 KO |
CNS, spinal cord, neuromuscular junction |
hSyn |
Rescue, FP |
3 months |
||||
PHP.eB |
POS |
Mouse, Crabp1 KO |
CNS, spinal cord, neuromuscular junction |
hSyn |
FP |
3 months |
||||
PHP.eB |
POS |
Mouse, mc1Bth/+ neonate |
Cochlea |
CMV, U6 |
CRISPR, CasRx sgRNA |
5E9 vg/site |
Round window membrane |
2 weeks |
||
PHP.eB |
POS |
Mouse, Tmc1+/+ |
Cochlea |
CMV, U6 |
CRISPR, CasRx sgRNA |
5E9 vg/site |
Round window membrane |
2 weeks |
||
PHP.eB |
POS |
Mouse, B6/C3H neonate |
CNS, all |
CMV, U6 |
Rescue sup-tRNA, FP |
1E11 vg/animal |
IV |
10 weeks |
||
PHP.eB |
POS |
Mouse, B6/C3H neonate |
CNS, all |
CMV, U6 |
Rescue sup-tRNA, FP |
2E11 vg/animal |
IV |
10 weeks |
||
PHP.eB |
POS |
Mouse, Fmr1-KO |
CNS, all |
CMV |
Rescue |
5E11 vg/animal |
RO |
4 or 8 weeks |
||
PHP.eB |
Mouse, C57BL/6J |
Muscle |
CMV |
FP |
1E12 vg/animal |
Intramuscular |
4 weeks |
|||
PHP.eB |
POS |
Mouse, Per2fl/fl |
CNS, astrocytes |
GFAP |
Recombinase, iCre, FP |
1E11 vg/animal |
Tail vein |
3 weeks |
||
PHP.eB |
POS |
Mouse, Per2fl/fl |
CNS, astrocytes |
CAG |
FP |
1E11 vg/animal |
Tail vein |
3 weeks |
||
PHP.eB |
NEG |
Mouse, Per2fl/fl |
CNS, astrocytes |
GFAP |
Recombinase, iCre, FP |
1E11 vg/animal |
Intraperitoneal, IP |
3 weeks |
||
PHP.eB |
POS |
Mouse, Per2fl/fl |
CNS, astrocytes |
GFAP |
Recombinase, iCre, FP |
1E11 vg/animal |
Intraperitoneal, IP |
2 months |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, neurons |
hSyn |
Rescue, FP, Epitope |
5E11 vg/animal |
RO |
3 weeks |
DOI: 10.7554/eLife.65417 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, excitatory neurons |
CamKIIa |
FP |
1E11 vg/animal |
IV |
3 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, gabaergic interneurons |
mDLX |
FP |
1E11 vg/animal |
IV |
3 weeks |
83900 |
|
PHP.eB |
POS |
Mouse, 3xTg-AD |
CNS, all |
CMV |
FP |
1E12 vg/animal |
Tail vein |
4 weeks |
||
PHP.eB |
POS |
Mouse, 3xTg-AD |
CNS, all |
CMV |
FP, Rescue |
1E12 vg/animal |
Tail vein |
4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6JRcc neonates |
CNS, hippocampus |
U6, hSyn |
shRNA, FP |
1-2E9 vg/site |
ICV |
3 weeks |
||
PHP.eB |
POS |
Rat, Sprague-Dawley |
CNS, all |
CAG |
FP |
6E11 vg/animal |
ICM |
1 month |
37825 |
|
PHP.eB |
NEG |
Rat, Sprague-Dawley |
CNS, all |
CAG |
FP |
6E10 vg/animal |
ICM |
1 month |
37825 |
|
PHP.B |
POS |
Mouse, Mcoln1−/− |
CNS, all |
CMV |
Rescue, FP |
1E12 vg/animal |
Tail vein |
4 weeks |
||
PHP.B |
POS |
Mouse, Mcoln1−/+ |
CNS, all |
CMV |
Rescue, FP |
1E12 vg/animal |
Tail vein |
4 weeks |
||
PHP.eB |
POS |
Mouse, Mmut−/− neonate |
CNS, neurons |
CamKIIa |
Rescue |
1E11 vg/animal |
RO |
3 weeks |
||
PHP.eB |
POS |
Mouse, Mmut−/− |
CNS, neurons |
CBA |
FP |
1E11 vg/animal |
RO |
3 weeks |
||
PHP.eB |
POS |
Mouse, Mmut+/− neonate |
CNS, neurons |
CamKIIa |
Rescue |
1E11 vg/animal |
RO |
3 weeks |
||
PHP.S |
POS |
Mouse, C57BL/6J |
PNS, trigeminal ganglia |
CAG |
FP |
0.7 - 5E11 vg/animal |
RO |
3 weeks |
||
PHP.S |
POS |
Mouse, PV-RTM |
PNS, Lumbar DRG |
hSyn |
FP |
1-2E11 vg/animal |
Intrathecal, lumbar |
2 weeks |
||
PHP.S |
POS |
Mouse, PV-RTM |
PNS, Lumbar DRG |
hSyn |
FP |
1-2E11 vg/animal |
Tail vein |
2 weeks |
||
PHP.S |
POS |
Mouse, PV-Cre |
PNS, Lumbar DRG |
hSyn FLEX |
Chemogenetic, hM3Dq, FP |
1-2E11 vg/animal |
Intrathecal, lumbar |
8 weeks |
||
PHP.S |
NEG |
Mouse, C57BL/6J |
PNS, schwann cells |
CAG |
FP |
9E10 vg/animal |
Intrathecal |
6 weeks |
||
PHP.S |
NEG |
Mouse, C57BL/6J |
PNS, schwann cells |
CAG |
FP |
1E12 vg/animal |
Tail vein |
6 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J neonate |
CNS, neurons |
hSyn, U6 |
FP, shRNA |
ICV |
||||
PHP.eB |
POS |
Mouse, LSL-Cas9 |
CNS, neurons |
hSyn, U6 |
CRISPR, sgRNA, Recombinase, Cre |
5E11 vg/animal |
Tail vein |
2 weeks |
||
PHP.eB |
POS |
Mouse, LSL-Cas9 |
CNS, astrocytes |
GFAP, U6 |
CRISPR, sgRNA, Recombinase, Cre |
5E11 vg/animal |
Tail vein |
2 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
FP |
4E11 vg/animal |
Tail vein |
4 weeks |
|||
PHP.eB |
POS |
Mouse, Vglut2-Cre |
CNS, amygdala |
hSyn |
FP |
1.2E11 vg/animal |
RO |
3 weeks |
||
PHP.eB |
POS |
Mouse, neonate |
CNS, all |
CMV |
Rescue, FP |
2E11 vg/animal |
Intracardiac |
|||
PHP.B |
POS |
Mouse, C57BL/6J |
Cochlea |
hSyn |
Opsin, vf-Chrimson |
1E10 vg/site |
Round window membrane |
|||
PHP.eB |
POS |
Mouse, C57BL/6J |
Cochlea |
hSyn |
Opsin, vf-Chrimson-ES/TS |
1E10 vg/site |
Round window membrane |
|||
PHP.eB |
POS |
Mouse, KO ARSA |
CNS, all |
CAG |
Rescue |
5E11 vg/animal |
RO |
3 months |
||
PHP.eB |
POS |
Mouse, SstCre/+ neonate |
CNS, somatostatin neurons |
hSyn DIO |
Chemogenetic, hM4D(Gi), FP |
2E10 vg/animal |
ICV |
9 weeks |
44362 |
|
PHP.eB |
POS |
Mouse, SstCre/+ neonate |
CNS, somatostatin neurons |
hSyn DIO |
FP |
2E10 vg/animal |
ICV |
9 weeks |
50459 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CMV |
FP |
3E9 vg/site |
Intracranial (cortex, cerebellum) |
165441, 165442, 165443 |
||
PHP.S |
POS |
Mouse, Cck-Ires-Cre |
PNS, myenteric neurons |
CAG DIO |
FP |
5.7E11 vg/animal |
Tail vein |
2-3 weeks |
||
PHP.B |
POS |
Mouse, H11-Cas9 neonate |
CNS, all |
CAG U6 |
FP, CRISPR, sgRNA |
1E11 vg/animal |
ICV |
5-6 weeks |
||
PHP.B |
POS |
Mouse, H11-Cas9 neonate |
CNS, all |
CAG U6 |
FP, CRISPR, sgRNA |
2E11 vg/animal |
ICV |
5-6 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, neurons |
mGAD65 |
FP |
5E12 vg/animal |
RO |
3 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, neurons |
mDlx |
FP |
5E12 vg/animal |
RO |
3 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, neurons |
mGAD65 |
FP |
1E11 vg/site |
Intrcranial (cerebellum) |
|||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, neurons |
mDlx |
FP |
1E11 vg/site |
Intrcranial (cerebellum) |
|||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, neurons |
mGAD65 |
FP |
3E12 vg/animal |
RO |
3 weeks |
||
PHP.B |
POS |
Mouse, H11-Cas9 neonate |
CNS, all |
CBA U6 |
FP, CRISPR, sgRNA |
5E10 vg/animal |
ICV |
5-6 weeks |
||
PHP.eB |
POS |
Mouse, H11-Cas9 neonate |
CNS, all |
CBA U6 |
FP, CRISPR, sgRNA |
5E10 vg/animal |
ICV |
5-6 weeks |
||
PHP.B |
POS |
Mouse, H11-Cas9 neonate |
CNS, all |
CBA U6 |
FP, CRISPR, sgRNA |
2E11 vg/animal |
ICV |
5-6 weeks |
||
PHP.eB |
POS |
Mouse, H11-Cas9 neonate |
CNS, all |
CBA U6 |
FP, CRISPR, sgRNA |
2E11 vg/animal |
ICV |
5-6 weeks |
||
PHP.B |
POS |
Mouse, C57BL/6J |
CNS, all |
CBh |
miRNA |
1E12 vg/animal |
RO |
3-4 weeks |
||
AAV9.452sub.LUNG1 |
POS |
Mouse, C57BL/6J |
Lung, alveolar type 2 |
CAG |
FP |
5E11 vg/animal |
RO |
2 weeks |
104061 |
|
AAV9.452sub.LUNG1 |
POS |
Mouse, C57BL/6J |
Lung, alveolar type 2 |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
104061 |
|
Cu64labeled-PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
7E11 vg/animal |
Tail vein |
3 weeks |
||
Cu64labeled-CAP-B10 |
POS |
Mouse, C57BL/6J |
CNS, all |
CAG |
FP |
7E11 vg/animal |
Tail vein |
3 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
EF1a |
PET reporter |
2E11 vg/animal |
Tail vein |
3 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
Liver |
CAG |
FP |
7E11 vg/animal |
Tail vein |
3 weeks |
||
CAP-B10 |
POS |
Mouse, C57BL/6J |
Liver |
CAG |
FP |
7E11 vg/animal |
Tail vein |
3 weeks |
||
PHP.S |
NEG |
Mouse, C57BL/6J |
PNS, nodose ganglion |
CAG |
FP |
3E11 vg/animal |
RO |
3 weeks |
||
MaCPNS1 |
POS |
Mouse, C57BL/6J |
PNS, nodose ganglion |
CAG |
FP |
3E11 vg/animal |
RO |
3 weeks |
||
MaCPNS2 |
POS |
Mouse, C57BL/6J |
PNS, nodose ganglion |
CAG |
FP |
3E11 vg/animal |
RO |
3 weeks |
||
PHP.S |
NEG |
Mouse, C57BL/6J |
PNS, DRG |
CAG |
FP |
3E11 vg/animal |
RO |
3 weeks |
||
MaCPNS1 |
POS |
Mouse, C57BL/6J |
PNS, DRG |
CAG |
FP |
3E11 vg/animal |
RO |
3 weeks |
||
MaCPNS2 |
POS |
Mouse, C57BL/6J |
PNS, DRG |
CAG |
FP |
3E11 vg/animal |
RO |
3 weeks |
||
PHP.S |
NEG |
Mouse, C57BL/6J |
PNS, enteric ganglia |
CAG |
FP |
3E11 vg/animal |
RO |
3 weeks |
||
MaCPNS1 |
NEG |
Mouse, C57BL/6J |
PNS, enteric ganglia |
CAG |
FP |
3E11 vg/animal |
RO |
3 weeks |
||
MaCPNS2 |
NEG |
Mouse, C57BL/6J |
PNS, enteric ganglia |
CAG |
FP |
3E11 vg/animal |
RO |
3 weeks |
||
PHP.S |
NEG |
Mouse, C57BL/6J |
PNS, enteric ganglia |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
||
MaCPNS1 |
NEG |
Mouse, C57BL/6J |
PNS, enteric ganglia |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
||
MaCPNS2 |
POS |
Mouse, C57BL/6J |
PNS, enteric ganglia |
CAG |
FP |
1E11 vg/animal |
RO |
3 weeks |
||
MaCPNS2 |
POS |
Mouse, C57BL/6J |
PNS, colon |
hSyn |
FP |
3E11 vg/animal |
RO |
3 weeks |
51506 |
|
MaCPNS2 |
POS |
Mouse, C57BL/6J |
PNS, colon |
hSyn |
FP |
5E11 vg/animal |
RO |
3 weeks |
51506 |
|
MaCPNS2 |
POS |
Mouse, C57BL/6J |
PNS, colon |
hSyn |
FP |
7E11 vg/animal |
RO |
3 weeks |
51506 |
|
MaCPNS1 |
POS |
Mouse, C57BL/6J |
PNS, nodose ganglion |
CAG |
Sensor, GCaMP8s |
1E12 vg/animal |
RO |
3 weeks |
162380 |
|
MaCPNS1 |
POS |
Mouse, TRPV1-Cre neonate |
PNS, DRG |
hSyn DIO |
Chemogenetic, hM3Dq, FP |
3E11 vg/animal |
Intraperitoneal, IP |
6 weeks |
44361 |
|
MaCPNS1 |
POS |
Rat, Sprague-Dawley |
PNS |
hSyn |
FP |
2E13 vg/kg |
IV |
3 weeks |
||
MaCPNS2 |
POS |
Rat, Sprague-Dawley |
PNS |
hSyn |
FP |
2E13 vg/kg |
IV |
3 weeks |
||
MaCPNS1 |
POS |
NHP, marmoset |
CNS, all |
CAG |
FP |
3.5E13 vg/kg |
IV |
3 weeks |
||
MaCPNS2 |
POS |
NHP, marmoset |
CNS, all |
CAG |
FP |
3.5E13 vg/kg |
IV |
3 weeks |
||
MaCPNS1 |
POS |
NHP, marmoset |
PNS, DRG |
CAG |
FP |
3.5E13 vg/kg |
IV |
3 weeks |
||
MaCPNS2 |
POS |
NHP, marmoset |
PNS, DRG |
CAG |
FP |
3.5E13 vg/kg |
IV |
3 weeks |
||
MaCPNS1 |
POS |
NHP, marmoset |
PNS, enteric ganglia |
CAG |
FP |
3.5E13 vg/kg |
IV |
3 weeks |
||
MaCPNS2 |
POS |
NHP, marmoset |
PNS, enteric ganglia |
CAG |
FP |
3.5E13 vg/kg |
IV |
3 weeks |
||
MaCPNS1 |
POS |
NHP, rhesus macaque neonate |
CNS, all |
CAG |
FP |
2.5E13 vg/kg |
IV |
3 weeks |
||
MaCPNS2 |
POS |
NHP, rhesus macaque neonate |
CNS, all |
CAG |
FP |
2.5E13 vg/kg |
IV |
3 weeks |
||
MaCPNS1 |
POS |
NHP, rhesus macaque neonate |
PNS, DRG |
CAG |
FP |
2.5E13 vg/kg |
IV |
3 weeks |
||
MaCPNS2 |
POS |
NHP, rhesus macaque neonate |
PNS, DRG |
CAG |
FP |
2.5E13 vg/kg |
IV |
3 weeks |
||
MaCPNS1 |
POS |
NHP, rhesus macaque neonate |
PNS, enteric ganglia |
CAG |
FP |
2.5E13 vg/kg |
IV |
3 weeks |
||
MaCPNS2 |
POS |
NHP, rhesus macaque neonate |
PNS, enteric ganglia |
CAG |
FP |
2.5E13 vg/kg |
IV |
3 weeks |
||
PHP.S |
NEG |
Mouse, C57BL/6J |
PNS, DRG |
CAG |
FP |
1E12 vg/animal |
RO |
3 weeks |
||
MaCPNS1 |
POS |
Mouse, C57BL/6J |
PNS, DRG |
CAG |
FP |
1E12 vg/animal |
RO |
3 weeks |
||
MaCPNS2 |
NEG |
Mouse, C57BL/6J |
CNS, all |
hSyn |
FP |
3E11 vg/animal |
RO |
3 weeks |
||
MaCPNS2 |
NEG |
Mouse, C57BL/6J |
CNS, all |
hSyn |
FP |
5E11 vg/animal |
RO |
3 weeks |
||
MaCPNS2 |
NEG |
Mouse, C57BL/6J |
CNS, all |
hSyn |
FP |
7E11 vg/animal |
RO |
3 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
hSyn |
FP |
3E11 vg/animal |
RO |
3 weeks |
||
MaCPNS1 |
POS |
Mouse, C57BL/6J neonate |
PNS, DRG |
hSyn |
FP |
3E11 vg/animal |
Intraperitoneal, IP |
6 weeks |
||
MaCPNS2 |
POS |
Mouse, C57BL/6J neonate |
PNS, DRG |
hSyn |
FP |
3E11 vg/animal |
Intraperitoneal, IP |
6 weeks |
||
MaCPNS1 |
POS |
Rat, Sprague-Dawley |
CNS, all |
hSyn |
FP |
2E13 vg/kg |
IV |
3 weeks |
||
MaCPNS2 |
POS |
Rat, Sprague-Dawley |
CNS, all |
hSyn |
FP |
2E13 vg/kg |
IV |
3 weeks |
||
PHP.eB |
POS |
Mouse, EMX1-Cre |
CNS, neuons |
hSyn DIO |
Rescue, FP |
RO |
4 weeks |
|||
PHP.eB |
POS |
Mouse, IRSp53-cKO EMX1-Cre |
CNS, neurons |
hSyn DIO |
Rescue, FP |
RO |
4 weeks |
|||
PHP.eB |
POS |
Mouse, EMX1-Cre |
CNS, neurons |
hSyn DIO |
FP |
RO |
4 weeks |
|||
PHP.eB |
POS |
Mouse, IRSp53-cKO EMX1-Cre |
CNS, neurons |
hSyn DIO |
FP |
RO |
4 weeks |
|||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, excitatory neurons |
CamKIIa |
Chemogenetic, TurboID |
3E11 vg/animal |
RO |
4 weeks |
doi: 10.1021/acs.analchem.1c05212 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, astrocytes |
GFAP |
Chemogenetic, TurboID |
3E11 vg/animal |
RO |
4 weeks |
doi: 10.1021/acs.analchem.1c05212 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, neurons |
hSyn |
shRNA, FP |
2E11 vg/animal |
RO |
3-4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, astrocytes |
GFAP |
FP |
2E11 vg/animal |
IV |
5 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, astrocytes |
GFAP |
shRNA, FP |
2E11 vg/animal |
IV |
5 weeks |
||
PHP.eB |
POS |
Mouse, CX3CR1+/GFP |
CNS, astrocytes |
GFAP |
FP |
2E11 vg/animal |
IV |
5 weeks |
||
PHP.eB |
POS |
Mouse, RUBICON−/− |
CNS, astrocytes |
GFAP |
FP |
2E11 vg/animal |
IV |
5 weeks |
||
PHP.eB |
POS |
Mouse, Klb-CRE |
CNS, neurons |
hSyn DIO |
Chemogenetic, hM3Dq, FP |
RO |
44361 |
|||
PHP.eB |
POS |
Mouse, Klb-CRE |
CNS, neurons |
CAG FLEX |
FP |
RO |
28306 |
|||
PHP.eB |
POS |
Mouse, Sim1-cre |
CNS, neurons |
CAG FLEX |
Rescue |
2.5E11 vg/animal |
IV |
4 months |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, neurons |
CAG FLEX |
Rescue |
2.5E11 vg/animal |
IV |
4 months |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, all |
CMV |
FP |
1.5E13 vg/kg |
RO |
2 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, cerebellum |
CMV |
FP |
4E9 vg/mouse |
Intraparenchymal |
4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, cerebellum |
CMV |
FP |
4E9 vg/mouse |
Intraparenchymal |
7 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS |
FP |
5E11 vg/animal |
Tail vein |
20 weeks |
|||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS |
Rescue, FP |
5E11 vg/animal |
Tail vein |
20 weeks |
|||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS |
Rescue, FP |
5E11 vg/animal |
Tail vein |
20 weeks |
|||
PHP.eB |
POS |
Mouse, Fgf21-P2A-CRE |
CNS, all |
CAG FLEX |
FP |
RO |
2 weeks |
|||
PHP.eB |
POS |
Mouse, FGF21fl/fl |
CNS, neurons |
hSyn |
Recombinase, Cre |
RO |
2 weeks |
|||
PHP.eB |
POS |
Mouse, FGF21fl/fl |
CNS, all |
CMV |
FP |
RO |
2 weeks |
|||
PHP.eB |
POS |
Mouse, FGF21fl/fl |
CNS, all |
CMV |
Recombinase, Cre |
RO |
2 weeks |
|||
PHP.eB |
POS |
Mouse, Myo6C442Y/+ neonate |
Inner ear |
EF1a |
CRISPR, mxABE, sgRNA |
1.4E10 vg/site |
Cochlea |
2 weeks |
||
PHP.B |
POS |
Mouse, APP23.tau−/− |
CNS, neurons |
hSyn |
Rescue |
1E10 vg/site |
Intracranial (cortex, hippocampus) |
|||
PHP.S |
POS |
Mouse, Nav1.8Cre het |
PNS, all |
mini-Cav3.2 FLEX |
Chemogenetic, hM3Dq |
5E10 vg/animal |
Intrathecal, lumbar |
8 weeks |
||
PHP.eB |
POS |
Mouse, 5xFAD |
CNS, parvalbumin neurons |
E2 |
FP |
Intracranial (cortex) |
135631 |
|||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, parvalbumin neurons |
E2 |
FP |
Intracranial (cortex) |
135631 |
|||
PHP.eB |
POS |
Mouse, 5xFAD |
CNS, parvalbumin neurons |
E2 |
FP |
1E11 vg/animal |
RO |
2-3 weeks |
135631 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, parvalbumin neurons |
E2 |
FP |
1E11 vg/animal |
RO |
2-3 weeks |
135631 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, purkinje neurons |
L7 tTA TRE |
Rescue |
Intracranial (cerebellum) |
8 days |
|||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, neurons |
hSyn tTA TRE |
Rescue |
Intracranial (cerebellum) |
8 days |
|||
PHP.eB |
POS |
Mouse, Rbp4-Cre KL100 |
CNS, L5 cortical pyramidal neurons |
CAG FLEX |
Sensor, GCaMP7s |
2E13 vg/kg |
RO |
1-3 weeks |
||
PHP.eB |
POS |
Mouse, Gad2-Cre |
CNS, L1 cortical neurons |
CAG FLEX |
Sensor, GCaMP7s |
2E13 vg/kg |
RO |
1-3 weeks |
||
PHP.eB |
POS |
Mouse, Cux2-Cre |
CNS, L2/3 cortical neurons |
CAG FLEX |
Sensor, GCaMP7s |
2E13 vg/kg |
RO |
1-3 weeks |
||
PHP.eB |
POS |
Mouse, Scnn1-Cre |
CNS, L4 cortical neurons |
CAG FLEX |
Sensor, GCaMP7s |
2E13 vg/kg |
RO |
1-3 weeks |
||
PHP.eB |
POS |
Mouse, Ntsr-Cre |
CNS, L6 cortical neurons |
CAG FLEX |
Sensor, GCaMP7s |
2E13 vg/kg |
RO |
1-3 weeks |
||
PHP.eB |
POS |
Mouse, Rbp4-Cre |
CNS, neurons |
Syn FLEX tTA TRE |
Rescue |
2E13 vg/kg |
RO |
1-3 weeks |
||
PHP.eB |
POS |
Mouse, Sun1-GFP |
retina, astrocytes |
GFAP |
Recombinase, Cre |
2E9 vg/site |
subretinal |
4 weeks |
||
PHP.eB |
POS |
Mouse, Sun1-GFP |
retina, astrocytes |
GFAP |
CRISPR, CasRx sgRNA |
8E9 vg/site |
subretinal |
4 weeks |
||
PHP.eB |
POS |
Mouse, 129S2/SvHsd |
retina |
CMV |
FP |
5E10 vg/animal |
tail vein |
1 month |
||
PHP.eB |
POS |
Mouse, 129S2/SvHsd |
retina |
CMV |
FP |
7.5E8 vg/site |
intravitreal |
1 month |
||
PHP.eB |
POS |
Mouse, 129S2/SvHsd |
retina |
CMV |
FP |
6E6 vg/site |
subretinal |
1 month |
||
PHP.eB |
POS |
Mouse, 129S2/SvHsd |
retina |
CMV |
FP |
3E7 vg/site |
subretinal |
1 month |
||
PHP.eB |
NEG |
Mouse, 129S2/SvHsd |
retina |
CMV |
FP |
1.5E8 vg/site |
subretinal |
1 month |
||
PHP.eB |
NEG |
Mouse, 129S2/SvHsd |
retina |
CMV |
FP |
7.5E8 vg/site |
subretinal |
1 month |
||
PHP.eB |
POS |
Mouse, APP/PS1 |
CNS, astrocytes |
GfaABC1D |
FP |
RO |
2 weeks |
|||
PHP.eB |
POS |
Mouse, C57BL/6NTac |
CNS, astrocytes |
GfaABC1D |
FP |
RO |
2 weeks |
|||
PHP.S |
POS |
Mouse, C57BL/6J |
PNS, enteric ganglia |
hSyn |
FP |
1E12 vg/animal |
RO |
3 weeks |
||
PHP.S |
POS |
Mouse, C57BL/6J |
PNS, enteric ganglia |
CAG DIO |
FP |
3.3E11 vg/animal |
RO |
3 weeks |
||
PHP.S |
POS |
Mouse, C57BL/6J |
PNS, enteric ganglia |
CAG |
FP |
1E12 vg/animal |
RO |
3 weeks |
||
PHP.S |
Mouse, C57BL/6J |
PNS, enteric ganglia |
CAG |
FP |
3.3E11 vg/animal |
RO |
3 weeks |
|||
PHP.eB |
POS |
Mouse, C57BL/6J neonate |
CNS, all |
U6, ITR |
CRISPR, sgRNA, Rescue |
1E11 vg/animal |
IV |
2 weeks |
||
PHP.eB |
POS |
Mouse, Pigob/b neonate |
CNS, all |
U6, ITR |
CRISPR, sgRNA, Rescue |
1E11 vg/animal |
IV |
4 months |
||
PHP.eB |
POS |
Mouse, Pigob/− neonate |
CNS, all |
U6, ITR |
CRISPR, sgRNA, Rescue |
1E11 vg/animal |
IV |
4 months |
||
PHP.eB |
POS |
Mouse, Pigob/b neonate |
CNS, all |
nEF |
CRISPR, Cas9 |
1E11 vg/animal |
IV |
4 months |
87115 |
|
PHP.eB |
POS |
Mouse, Pigob/− neonate |
CNS, all |
nEF |
CRISPR, Cas9 |
1E11 vg/animal |
IV |
4 months |
87115 |
|
PHP.eB |
NEG |
Mouse, Lkb1fl/fl |
CNS, neurons |
hSyn |
Recombinase, Cre, FP |
RO |
||||
PHP.eB |
Mouse, Lkb1fl/fl |
CNS, neurons |
hSyn |
FP |
RO |
|||||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, parvalbumin neurons |
Ef1a |
FP |
4E11 vg/animal |
RO |
3-4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, parvalbumin neurons |
SC1 |
FP |
4E11 vg/animal |
RO |
3-4 weeks |
||
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, parvalbumin neurons |
SC2 |
FP |
4E11 vg/animal |
RO |
3-4 weeks |
||
PHP.eB |
POS |
Mouse, Slc17a7-Cre |
CNS, neurons |
Syn FLEX tTA TRE |
FP |
RO |
||||
PHP.S |
POS |
Mouse, Mafb-mCherry-Cre |
PNS, cranial sensory gangion |
CAG FLEX |
Sensor, GCaMP6s |
2.9E12 vg/animal |
RO |
2 weeks |
100842 |
|
PHP.S |
POS |
Mouse, Penk-Cre |
PNS, cranial sensory gangion |
CAG FLEX |
Sensor, GCaMP6s |
2.9E12 vg/animal |
RO |
100842 |
||
PHP.S |
POS |
Mouse, C57BL/6J |
PNS, cranial sensory gangion |
CAG |
FP |
1.3E12 vg/animal |
RO |
2 days |
37825 |
|
PHP.S |
POS |
Mouse, C57BL/6J |
PNS, cranial sensory gangion |
CAG |
FP |
1.3E12 vg/animal |
RO |
4 days |
37825 |
|
PHP.S |
POS |
Mouse, C57BL/6J |
PNS, cranial sensory gangion |
CAG |
FP |
1.3E12 vg/animal |
RO |
1 week |
37825 |
|
PHP.S |
POS |
Mouse, C57BL/6J |
PNS, cranial sensory gangion |
CAG |
FP |
1.3E12 vg/animal |
RO |
2 weeks |
37825 |
|
PHP.S |
POS |
Mouse, C57BL/6J |
PNS, cranial sensory gangion |
CAG |
FP |
1.3E12 vg/animal |
RO |
3 weeks |
37825 |
|
PHP.S |
POS |
Mouse, Mafb-mCherry-Cre |
PNS, cranial sensory gangion |
CAG FLEX |
Sensor, GCaMP6s |
2.9E12 vg/animal |
RO |
19 days |
100842 |
|
PHP.eB |
POS |
Mouse, C57BL/6J |
CNS, astrocytes |
GFAP |
FP |
4.9E11 vg/animal |
Tail vein |
3 weeks |
||
PHP.eB |