Novel BBB regulators verified with AAV9-X1.1

Former CLOVER Research Scientist Xinhong Chen, in collaboration with the laboratory of Jiefu Li at HHMI's Janelia Research Campus, used AAV9-X1.1 to validate blood-brain barrier (BBB) regulators that the Li lab identified through luminal surface proteomics of the brain vasculature. The multi-institutional team reports that Slc7a1 is key to neonatal but not adult BBB maintenance, whereas HYAL2 is required throughout the mouse lifespan.

Check out the full story in Science. Congrats Xinhong!