In this paper we describe several vector tools for studying the central and peripheral nervous systems, including two capsids AAV-PHP.eB and AAV-PHP.S and a collection of AAV genomes.
Global representations of goal-directed behavior in distinct cell types of mouse neocortex"Allen, W.E., Kauvar, I.V., Chen, M.Z., Richman, E.B., Yang, S.J., Chan, K., Gradinaru, V., Deverman, B.E., Luo, L., Deisseroth, K. Neuron, 2017;94, 891-907. [Article]
Hillier, D., Fiscella, M., Drinnenberg, A., Trenholm, S., Rompani, S. B., Raics, Z., et al. (n.d.). Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex. Nature Neuroscience, advance online publication SP - EP . [Article]
Bone CLARITY: Clearing, imaging, and computational analysis of osteoprogenitors within intact bone marrow" Greenbaum, A.*, Chan, K.Y.*, Dobreva, T., Brown, D., Balani, D.H., Boyce, R., Kronenberg, H.M., McBride, H.J., Gradinaru, V. Sci Transl Med, 2017; 9, eaah6518. [ Article | Caltech News Release | Nature Research Highlights | Popular Science]
Ken now joins the CLOVER Center as a postdoctoral fellow applying AAV-PHP vectors to the study and potential treatment of Huntington's disease.